Institut Francais De Recherche Pour L'exploitation De La Mer (ifremer)

Université René Descartes Paris 5

UniversitÉ Paris Descartes

Institut Francais De Recherche Pour L'exploitation De La Mer

Gaston-Jacques Godeau

Sylvia Colliec-Jouault

Corinne Sinquin

Karim Senni

Jean Guezennec

Jacqueline Ratiskol

Gérard Raguenes

Anthony Courtois

Farida Gueniche

Myriam Yousfi

Florence Fioretti

Patrick Durand

Sylvie Igondjo-Tchen Changotade

Alexandrine Foucault-Bertaud

Grégory Korb

Maya Brigitte Baroukh

Jean-Louis Saffar

Miriam Yousfi

Gerard Raguenes

Gregory Korb

Farida Geuniche

The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 &#x3bc;g (m) g/ml.

Sulfated depolymerized derivatives of exopolysaccharides (EPS) from mesophilic marine bacteria, method for preparing same, and uses thereof in tissue regeneration

The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 &#x3bc;g (m) g/ml.

Sulfated depolymerized derivatives of expolysaccharides (EPS) from mesophilic marine bacteria, method for preparing the same, and uses thereof in tissue regeneration

The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.

Bone substitute comprising fucans and methods of making and use thereof

Growing community of inventors

Antony, France

Gaston-Jacques Godeau