Plexxikon Inc.

Gaston G Habets

Prabha N Ibrahim

Chao Zhang

Marika Nespi

Jiazhong Zhang

Wayne Spevak

Brian L West

Dean R Artis

Ryan Bremer

Shumeye Mamo

Klaus-Peter Hirth

Rebecca Zuckerman

Guoxian Wu

Yong-Liang Zhu

Songyuan Shi

Gideon Bollag

Clarence R Hurt

Heike I Krupka

Abhinav Kumar

Elizabeth A Burton

Hanna Cho

Shenghua Shi

Hongyao Zhu

James Tsai

Jianming Tsai

Yoshihisa Suzuki

Samuel J Gillette

Yoshisa Suzuki

Yong Zhu

Helke Krupka

Richard Dean Artis

Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Compounds for kinase modulation, and indications therefor

Compounds, compositions and methods useful for treatment of Flt3-mediated diseases or conditions are provided herewith. Also provided herewith are methods for modulating the receptor protein tyrosine like kinase 3(Flt3).

Kinase modulation and indications therefor

Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Compounds and methods for kinase modulation, and indications therefor

Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.

Compounds and methods for development of Ret modulators

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Pleasant Hill, CA, United States of America

Gaston G Habets