Asl Analytical, Inc.

Gary Wray Small

Mark Allen Arnold

Jonathon Todd Olesberg

Christine Esther Evans

Edwin John Koerperick

A system and method for continuous, real-time process monitoring and control by means of near-infrared (NIR) spectroscopy provides analysis of static or flowing fluid streams which may range from clear to highly optically dense, including fluids primarily of aqueous composition. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness in laboratory and industrial settings.

Apparatus and method for automated process monitoring and control with near infrared spectroscopy

An optical sampling apparatus for disposable flexible bioprocessing vessels includes features for optical interrogation of the vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the vessels during bioprocesses.

Near-infrared optical interfaces for disposable bioprocessing vessels

An optical probe with associated disposable polymer sheath for near-infrared optical interrogation of fluids within bioprocessing vessels by means of transmission or transflection spectroscopy provides for the determination of quantities and parameters of substances in fluids contained within bioprocessing vessels. Associated methods for use of the optical probe and associated sheath to determine quantities of substances in fluids and parameters of fluids during bioprocesses are provided.

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Coralville, IA, United States of America

Gary Wray Small