Medtronic, Inc.

Medtronics, Inc.

Micron Devices LLC

Meadtronic, Inc

Gary William King

Steven M Goetz

Kenneth Timothy Heruth

Jeffrey T Keacher

Mark Turner Rise

Andrew H Houchins

Michael J Schendel

Thomas E Cross, Jr

Ethan A Rooney

Paul W Wacnik

Carl D Wahlstrand

Roy L Testerman

Jordan J Greenberg

Xiaohong Zhou

Thomas J Mullen

Michael R S Hill

Richard S Schallhorn

Nathan Andrew Torgerson

Michael Thomas Lee

Joseph J Nolan

Gabriela C Miyazawa

Jeffrey S Evanson

Richard T Stone

Michael D Baudino

Warren L Starkebaum

Daryle Petersen

Frans L Gielen

Mark S Lent

John Rondoni

Jon P Davis

Rajeev Madhukar Sahasrabudhe

Gregory Anthony Hrdlicka

Wende L Dewing

Greg Hrdlicka

Robert Leinders

Donald R Johnson

Wilbert Wesselink

Theodore J Stone

Kevin K Tidemand

Robert W Stadler

David L Thompson

James M Olsen

Laura Tyler Perryman

John E Burnes

Eric H Bonde

Chad David Andresen

Mark A Christopherson

Gabriela C Molnar

Dennis D Elsberry

Ruchika Singhal

Steven N Lu

Anthony Yeung

Rick S Schallhorn

Jeff Jelen

Steve R Laporte

Marcus J Mianulli

Thomas R Moore

Rob Leinders

Wilbert A Wesselink

Steven Ning Lu

Gabriela C Miyazawa Molnar

Wibert A Wesselink

Richard Schallorn

Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.

Peripheral nerve field stimulation control

Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.

Combination therapy including peripheral nerve field stimulation

A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.

Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions

A therapy program for peripheral nerve field stimulation (PNFS) may be selected based on user input indicating a desired therapeutic effect for a user-specified region in which a patient feels pain. In other examples, PNFS may be programmed based on input from a user selecting at least one region from among a plurality of regions in which the patient experiences pain. In addition, the PNFS may be programmed based on user input defining an aspect of PNFS for the selected region, such as a relative intensity of PNFS delivered to at least two selected regions, a balance of PNFS between at least two regions, a desired shift in PNFS from a first region to a second region, or an extent to which a first stimulation field within a first region overlaps with a second stimulation field in a second region.

Programming techniques for peripheral nerve field stimulation

Peripheral nerve field stimulation (PNFS) delivered by medical device to a patient may be programmed by specifying one or more characteristics of a stimulation field generated by the IMD to provide the PNFS. The characteristics of the stimulation field may include, for example, a direction of stimulation within the field, a breadth of the stimulation field, a focus of stimulation within the stimulation field, a depth of the stimulation field relative to a reference point, such as the epidermis of the patient, or a nerve fiber diameter selection.

Peripheral nerve field stimulation and spinal cord stimulation

The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.

Shifting between electrode combinations in electrical stimulation device

The disclosure describes an introducer for facilitating implantation of therapy elements into a patient. The introducer has an elongated body that defines a lumen for advancement of a therapy element to an implant site, and includes a curved portion medially located between substantially straight proximal and distal portions. As an example, the shape of the introducer may allow a clinician to more easily, and without substantially damaging surrounding tissue, find the correct tissue depth and follow that tissue depth to the implant site. For example, the introducer may facilitate implantation of a therapy element within or between desired layers of tissue of the patient. In some embodiments, fluid may be injected through the introducer to create a space within the tissue to implant the therapy element. Fluid may also be evacuated through the introducer prior to implantation.

Introducer for therapy delivery elements

An implantable neurostimulation lead kit adapted for tripolar electric simulation and/or field steering using percutaneously implantable electric stimulation leads. The kit includes three electric stimulation leads that are adapted to provide an electrode array defining, for example, a plurality of electrode sets that may be used to provide tripolar stimulation and/or electric field steering. A method of electrically stimulating the spinal cord is also described.

Transverse tripole neurostimulation methods, kits and systems

An implantable neurostimulation lead, method and system adapted for tripolar electric simulation and/or field steering. The neurostimulation lead is are adapted to provide an electrode array defining, for example, a plurality of electrode sets that may be used to provide tripolar stimulation and/or electric field steering.

Transverse tripole neurostimulation lead, system and method

A method for modulating nerve tissue in a body of a patient includes implanting a wireless stimulation device in proximity to a dorsal root ganglion or an exiting nerve root such that an electrode, circuitry and a receiving antenna are positioned completely within the body of the patient. An input signal containing electrical energy and waveform parameters is transmitted to the receiving antenna(s) from a control device located outside of the patient's body via radiative coupling. The circuitry within the stimulation device generates one or more electrical impulses and applies the electrical impulses to the dorsal root ganglion or the exiting nerve roots through the electrode.

Methods and devices for modulating excitable tissue of the exiting spinal nerves

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Fridley, MN, United States of America

Gary William King