The Ohio State University

Albany International Corporation

Gary W Morrow

Waldemar A Priebe

John S Swenton

Derek Horton

Clyde E Bishop

Compounds represented by the formula (I) ##STR1## wherein R is hydrogen or hydroxyl, one of X and Y is fluorine and the other is hydrogen or both X and Y are fluorine, and Su is a hydrogen atom or a sugar moiety; where Su is a sugar moiety, the compounds are useful anticancer antibiotics; pharmaceutical preparations containing the antibiotics and a method for inhibiting the growth of mammalian tumors are also disclosed.

1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics

Anthracycline antibiotics represented by the formula (I) ##STR1## wherein R is hydrogen or hydroxyl, one of X and Y is fluorine and the other is hydrogen or both X and Y are fluorine, and S is a 2-halo sugar moiety; pharmaceutical preparations containing the same; and a method for inhibiting the growth of mammalian tumors are disclosed.

1-fluoro, 4-fluoro, and 1,4-difluoro-2'-halo anthracycline antibiotics

A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.

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Columbus, OH, United States of America

Gary W Morrow