Commonwealth Scientific and Industrial Research Organisation

Biotech Australia Pty Ltd

Biotechnology Australia Pty, Ltd

Other

Biotech Australia Pty. Limited and Csiro

Gary Stewart Cobon

Barry Maxwell Wagland

Alagacone Sriskantha

Phillip John Sharp

Keith Norman Rand

Keith William Savin

Maurice Joseph Frenkel

Joanna Terry Moore

David Harold Kemp

William Peter Kennedy

Peter Willadsen

Ian Joseph O'Donnell

George Alfred Riding

Rosemary Ann Austen

Law A Johnston

Law Anthony Yorke Johnston

This invention relates to an antigen isolated from the cattle tick,and to the gene coding for that antigen and to the protein product of that gene. The antigen when used in part or in entirety as an immunogen administered to cattle as a vaccine results in the production by the cattle of an immune response which is capable of damaging ticks feeding on vaccinated cattle to such an extent that the survival of such ticks is decreased and/or the reproductive capacity of the ticks is decreased to such an extent that the antigen coded for by the gene can be used as an effective vaccine against said ticks.

DNA encoding a cell membrane glycoprotein of a tick gut

Disclosed is a substantially purified antigen derived from a first species of parasitic nematodes, which antigen is capable of providing protection to a host from parasitism infestation by a second nematode species, which may be the same as or different from the first nematode species, following vaccination of the host with the antigen, characterized in that the antigen is proteinaceous, has a pI between 3.8 and 4.4, can be bound by lentil lectin and Helix promatia and has a molecular weight of approximately 45 kD as determined by SDS-PAGE.

Nematode vaccine

The invention disclosed relates to proteins derived from parasitic nematodes that confer protective immunity against infection by parasitic nematodes, to nucleotide sequences encoding those proteins, to recombinant molecules containing such sequences, to host cells transformed with such recombinant molecules and methods for the production of the nucleotide sequences, recombinant molecules and hosts. The invention also relates to vaccines comprising proteins of the invention together with suitable carriers or diluents and to antibodies raised against proteins of the invention.

Vaccines against animal parasitic nematodes

Disclosed is the invention relates to proteins derived from parasitic nematodes which confer protective immunity against infection by parasitic nematodes, to nucleotide sequences encoding these proteins, to recombinant molecules containing such sequences to host cells transformed with such recombinant molecules and methods for the production of the nucleotide sequences recombinant molecules and hosts. The invention also relates to vaccines comprising proteins of the invention together with suitable carriers or diluents and to antibodies raised against proteins of the invention.

The invention relates to antigens derived from ticks and to their purification. It also relates to genes encoding such antigens and to their cloning and expression from recombinant DNA molecules. Further, the invention describes the use of purified antigens and recombinant expression products having similar biological activity to those purified antigens to provide vaccines to protect cattle against tick infestation.

Haemonchus contortus vaccine

Growing community of inventors

Frenchs Forest, Australia

Gary Stewart Cobon