Becton Dickinson and Company Limited

Gary Siuzdak

James G Nadeau

Richard L Moore

Song Shi

Robert W Rosenstein

Nicholas Robert Bachur, Jr

James A Garrett

Gregory Tice

Donald W Copertino

Thomas M Gentle, Jr

Paul Ernest Goldenbaum

Richard Ivey

Michael L Towns

Elizabeth J Want

Zhouxin Shen

Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.

Mass spectrometry techniques for determining the status of sepsis in an individual

Method of predicting the onset of sepsis in SIRS-positive individuals using mass spectrometry

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San Diego, CA, United States of America

Gary Siuzdak