Kineta Two, LLC

Illumigen Biosciences, Inc.

University of Washington

Gary Rosenberg

Shawn P Iadonato

Charles Lee Magness

Christina A Scherer

Thierry Guillaudeux

Michael G Katze

Roger Bumgarner

Mariya Smit

Michael Katze

A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.

Detection of mutations in a gene associated with resistance to viral infection, OAS1

Methods for the diagnosis of hepatocellular carcinoma (HCC) are set forth. Improved assay methods and scanning methods are included that employ non-cell-associated and cell-associated HCC related proteins. Such methods are based upon the discovery of genes that were up-regulated in diseased versus normal tissue as well as in HCC tissue when compared to the tissue of patients with other ailments.

Methods and compositions for diagnosing hepatocellular carcinoma

Growing community of inventors

Danbury, CT, United States of America

Gary Rosenberg