The Brigham and Women's Hospital, Inc.

Gary R Strichartz

Stephen A Raymond

James H Philip

Daniel B Raemer

Martyn A Vickers, Jr

Markus Schneider

Sanjay Datta

A method of using veratridine to inhibit nerve impulses, and a composition of matter including veratridine and epinephrine, is provided. Application of veratridine proximal to a nerve causes depolarization of the nerve membrane, thereby blocking transmission of nerve impules. C-fiber selectivity is demonstrated in vitro in rabbit vagus nerves. Veratridine displays extended anesthetic activity over long periods of time when compared to similar local anesthetics, with no local toxicity. Systemic toxicity is reduced by co-injection with epinephrine.

A composition and a method of using veratridine and epinephrine as a

The present invention is directed to a method and apparatus for locating and identifying the function of specific peripheral nerves. In one embodiment, the present invention takes the form of a nerve stimulator which is used to locate nerves to assist in the administration of regional anesthesia. In another embodiment, the nerve stimulator is used to locate, identify the function of, and guard against the inadvertent cutting of specific nerves during surgical procedures. The apparatus of the present invention includes a stimulus delivery means, a response-detecting means and a means for automatically modulating the magnitude of the stimulus.

Apparatus for locating a nerve and for protecting nerves from injury

Method for locating a nerve and for protecting nerves from injury during

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West Roxbury, MA, United States of America

Gary R Strichartz