Scriptgen Pharmaceuticals, Inc.

Other

Boston University

Arqule, Inc.

Solvay Pharmaceuticals, B.v.

Gary R Gustafson

Mark A Wuonola

James S Panek

Jennifer V Schaus

Tao Hu

David G Powers

Maria L Pras-Raves

Jan H Reinders

Guustaaf Jm Van Scharrenburg

Tau Hu

Jacobus Aj Den Hartog

The present invention is a solar panel that generates electricity and extracts heat. A set of such panels may be assembled into a blind. The blind may have a frame that can be retrofit on an existing window. Fluid in the panel is heated by incoming solar radiation, causing it to move, constrained by a one-way valve, in one direction. A Tesla Valve may be used as the one-way valve. The moving fluid may pass through a generator, generating electricity. Heat may be extracted from the fluid by a heat exchanger. The heat may be used to heat a building.

Solar panels that generate electricity and extract heat: system and method

The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-Areceptors, as well as to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient. The invention relates to compounds of the general formula (1) wherein Y represents a group of the general formula (A), (B) or (C) and all other symbols have the meanings as given in the description.

1,3,5-Triazine derivatives as ligands for human adenosine-A3 receptors

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

Pyronin antibacterials, process and novel intermediates thereto

2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.

Use of 2-deoxystreptamine as a molecular scaffold for the preparation of

This invention provides a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.3 independently are hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, --A--Ar--(Q).sub.z, etc.; wherein D is a C.sub.1-6 linear, C.sub.3-8 branched or cyclic group having from 4 to about 15 atoms, consisting of C, etc.; wherein D is unsubstituted or substituted with one or more groups independently selected from the group consisting of --OH, NH.sub.2, --NHR.sub.7, etc.; wherein each Q is independently --CNH(NHY), --NHCNH(NHY), --SO.sub.2 W, --SOW, etc.; wherein Y is hydrogen, alkyl, alkenyl, --B--NH.sub.2, --B--NHR.sup.8, etc.; wherein W is alkyl, alkenyl, --B--NH.sub.2, etc.; wherein A nd B independently are a bond, or a C.sub.1-6 linear, C.sub.3-8 branched or cyclic linking group having from 1 to about 15 atoms, consisting of C, optionally interrupted by N, S, P and O; wherein A and B independently are unsubstituted or substituted with --OH, NH.sub.2, etc.; wherein R.sup.7 is an alkyl, a branched alkyl, etc.; wherein R.sup.8, R.sup.9, and R.sup.10 are independently represented by hydrogen, alkyl, branched alkyl, etc.; wherein x is 0, 1 or 2; and z is 0, 1, 2, or 4; wherein R.sup.1 ' and R.sup.3 ' are independently selected from the group consisting of hydrogen, alkyl and benzyl, or alternatively, R.sup.1 and R.sup.1 ' or R.sup.3 and R.sup.3 ' with their respective nitrogen atoms independently form a phthalimido, succinimido, etc.; wherein R.sup.4, R.sup.5, and R.sup.6 independently are selected from the group consisting of hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, etc.; therein said saccharides are optionally linked at the one position of said saccharid group; wherein R.sup.4 and R.sup.5, or R.sup.5 and R.sup.6, together comprise a methylidene, ethylidene, isopropylident, cyclohexylidene or benzylidene bridge, or R.sup.3 and R.sup.4, or R.sup.1 and R.sup.6, together independently form an intramolecular carbamate; wherein R.sup.5 is not hydrogen or glycosyl when R.sup.3 and R.sup.4, or R.sup.1 and R.sup.6, together independently form an intramolecular carbamate; with the provisio that at least two of R.sup.1, R.sup.1 ', R.sup.3, R.sup.3 ', R.sup.4, R.sup.5, and R.sup.6 are not hydrogen. Also provided are pharmaceutical compositions comprising the compound and methods of inhibiting binding of human immunodeficiency virus REV protein to RRE.

2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and

A solar collector is designed for use in the window opening of a house and also serves to retain the window function for the occupants of the house. The collector has a rectangular frame having an inner pane of glass, an outer pane or panes and a plurality of rotatable louvers mounted in the frame between the inner and outer panes. The louvers have a reflective material on one side and a dark or solar absorbing surface on the other, thereby allowing the proper side to be rotated into position depending on the season. A heated chamber is provided within the louvers so that the working fluid may flow directly through the louvers and allow the heat transfer to occur therein.

Growing community of inventors

Bedford, MA, United States of America

Gary R Gustafson