Wyeth

American Home Products Corporation

Other

Elan Pharmaceuticals, Inc.

Gary Paul Stack

Megan Tran

Jonathan Laird Gross

Magid A Abou-Gharbia

Richard Eric Mewshaw

Dahui Zhou

Deborah Ann Evrard

Hong Gao

Adam Matthew Gilbert

Young H Kang

George E M Husbands

Rulin Zhao

Noreen T Scherer

Terrance H Andree

Eugene D Thorsett

Michael A Pleiss

Amedeo A Failli

Darren B Dressen

Ian A Cliffe

Anthony Frank Kreft

Annmarie Louise Sabb

Reinhardt Bernhard Baudy

Thomas D Golobish

Dennis Michael Kubrak

Magda Asselin

Uresh Shantilal Shah

John A Moyer

Michael Byron Webb

Charles William Mann

Edward J Podlesny

Byron Abel Bravo

Byron A Bravo

Elizabeth S Gildersleeve

Guy A Schiehser

John P Yardley

Eugene John Trybulski

Paige Erin Mahaney

James Albert Nelson

Neal Green

Gavin David Heffernan

Lihren Chen

Alexander Greenfield

Joseph Peter Sabatucci

Wayne E Childers, Jr

Anita Wai-Yin Chan

Steve Yikkai Tam

Jianxin Ren

Jason Shaoyun Xiang

Lalitha Krishnan

Robert Lewis Vogel

Yanfang Li

Lori Krim Gavrin

G E Husbands

Nicole T Hatzenbuhler

William DeMaio

Charles Guinosso

Susan Christman Croce

Scott C Berta

Antonia Nikitenko

Marla Jean Williams

Ronald A Jordan

Matthew Hoffmann

Jean Yi-ching Sze

Audrey Molina Davies

Uresh Shantilah Shah

Jianyao Wang

John Chuck Lem Erve

Rasmy Elsayed Talaat

Charles John Stanton, Iii

Dahul Zhou

John Dunlop

Michael Bryon Webb

Aranapakam Madumbai Venkatesan

Rodney W Lappe

Young Hee Kang

Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists and partial agonists of the 2c subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Dihydrobenzofuranyl alkanamines and methods for using same as cns agents

Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan

Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Antidepressant piperidine derivatives of heterocyclefused benzodioxans

Compounds of formula I are provided: wherein each of R, R, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of melatoninergic receptors. The compounds, and compositions containing the compounds, can be used to treat melatoninergic disorders.

Dihydrobenzofuran derivatives and uses thereof

Compounds of Formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Dihydrobenzofuranyl alkanamine derivatives and methods for using same

Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans

The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Fused-aryl and heteroaryl derivatives and methods of their use

Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R, R, R, R, R, R, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.

Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and are also useful for the treatment of disorders such as anxiety, aggression and stress, and for the control of various physiological phenomena, such eating disorders, disorders of thermoregulation, and sleep and sexual dysfunction.

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Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R, R, R, R, R, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Benzofuranyl alkanamine derivatives and uses thereof

Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R, R, R, R, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Chromane and chromene derivatives and uses thereof

The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HTreceptors and modulating serotonin levels.

Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives

Quinoline 3-amino chroman derivatives and compositions containing such compounds are disclosed. Methods for using the quinoline 3-amino chroman derivatives and compositions containing such compounds in the treatment of serotonin disorders are disclosed. Also disclosed are processes for preparing quinoline 3-amino chroman derivatives.

Quinoline 3-amino chroman derivatives

Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans

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Ambler, PA, United States of America

Gary Paul Stack