Warner-lambert Company

Gary P Shrum

David T Connor

Paul C Unangst

Catherine R Kostlan

Daniel L Flynn

Michael William Wilson

Michael D Mullican

The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.

3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and

Novel 5, 6, or 7 membered oxaza heterocycles substituted at the 4-carbon by a 5-hydroxypyrimidinylmethylene group inhibitors of 5-lipoxygenase and/or cyclooxygenase and are thus useful in treating inflammatory diseases are described as well as pharmaceutical compositions, methods of manufacture of the compounds, and compositions and methods of treating the noted diseases.

5-hydroxy-2-pyrimidinylmethylene oxaza heterocycles

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Ann Arbor, MI, United States of America

Gary P Shrum