Thetis Pharmaceuticals LLC

Other

Beth Israel Deaconess Medical Center, Inc.

Gary Mathias

Frank C Sciavolino

Michael C Van Zandt

Gunnar Erik Jagdmann, Jr

Jessica J Dworak

Banavara L Mylari

Dipak Panigrahy

John Parkinson

Aaron Mathias

The present invention relates to compositions comprising resolvins and their use in methods of treating cancer.

Compositions and methods for cancer therapy

The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

Compositions and methods relating to salts of specialized pro-resolving mediators

The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both. Provided are pharmaceutical compositions adapted to deliver the compounds the lower gastrointestinal tract and methods of using same as monotherapy in the treatment of inflammatory diseases or disorders of the lower gastrointestinal tract, and in combination therapy with 5-aminosalicylate.

The present invention relates to compounds of Formulas I-IV and compositions comprising same, including pharmaceutical compositions. The compounds of Formulas I-IV represent new salt forms of specialized pro-resolving mediators ('SPMs') which include lipoxins, resolvins, protectins, and their aspirin-triggered counterparts. The SPM salts described here contain at least one or two SPM molecules ionically bound to at least one basic function that is provided by a scaffold as described in Formulas I-IV. Also provided are methods for pharmaceutical and non-pharmaceutical uses of such compounds and compositions describing same.

The present invention relates to compounds of Formula IV, compositions comprising same, and their use in therapy wherein A and B are each independently a specialized pro-resolving mediator ('SPM') molecule selected from an E series resolvin, a D series resolvin, and their aspirin-triggered counterparts, and M, R, R, Xand Xare as defined herein.

The present invention relates to compounds which are salts of specialized pro-resolving mediators (referred to herein as 'SPMs') which include lipoxins, resolvins, protectins, and their aspirin-triggered counterparts. The SPM salts described here contain at least one or two SPM molecules ionically bound to at least one basic function that is provided by a scaffold moiety as described herein, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

The present invention provides compounds of Formula I and related compositions and methods.

Mineral amino-acid complexes of active agents

The present invention relates to compounds of Formula I, compositions containing same, and methods of use.

Compositions and methods relating to ionic salts of peptides

The present invention relates to compound of Formula III comprising an amino acid component, a divalent metal component, and a counter-ion component, compositions containing same, and methods of use.

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Ridgefield, CT, United States of America

Gary Mathias