Bristol-Myers Squibb Compnay

Gary M Lim

John M Roubie

Elizabeth A Garofalo

Murray A Kaplan

Vicki H Audia

The cephalosporin intermediates, desacetyl 7-glutaryl ACA and desacetyl cephalosporin D, are obtained in the form of a concentrated aqueous solution from an aqueous solution containing said intermediates in less concentrated form by solvent extraction using cyclohexanone followed by back-extraction into water. The concentrated aqueous solution of intermediate is in a form which can be used for economical production of 7-ACA using known procedures.

Cyclohexanone extraction of 3-hydroxymethylcephalosporins

The present invention provides a stable, crystalline syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride substantially free of the anti-isomer and a process for the preparation thereof which may be used in an acylation process for the preparation of useful broad-spectrum antibiotics.

Syn-isomer of thiazolyl intermediate and process for the preparation

The present invention provides an aqueous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA..sup.2 isomer comprising the N-acylation of 7-amino-3-[(1-methyl-1-pyrrolidinio)-methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.

Preparation of a cephalosporin antibiotic using the syn-isomer of a

The present invention provides a process for the preparation of stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI, HCl or H.sub.2 SO.sub.4 which are substantially free of the .DELTA..sup.2 isomer, and which are convertible into broad-spectrum cephalosporin antibiotics.

Process for preparing cephalosporin intermediates

The present invention provides an anhydrous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA..sup.2 isomer comprising the N-acylation of a silylated derivative of 7-amino-3-[(1-methyl-1-pyrrolidinio)-methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.

Process for the preparation of a cephalosporin antibiotic

The present invention relates to a new crystalline dihydrochloride dihydrate salt of the cephalosporin antibiotic, cefepime. In particular, this invention provides a temperature and moisture stable crystalline dihydrochloride dihydrate form of cefepime having enhanced stability and a specific x-ray powder diffraction pattern as described herein.

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Fayetteville, NY, United States of America

Gary M Lim