Columbia University

New York University

Ferrosens Gmbh

Gary M Brittenham

Herbert Stepp

Georg Hennig

Jens Jensen

Daniel Kim

Michael Grossmann

Christian Homann

Michael Grossman

The present invention is directed to an apparatus () for reliable quantitative measurement of a fluorescent blood analyte in tissue () comprising: at least one light source (), the light source () emitting excitation light at least at a first wavelength range between 350 nm and 450 nm to the tissue (); a detection unit (), the detection unit () measuring: a) a portion of the fluorescent light emitted by the fluorescent blood analyte excited at the first wavelength range; and b) a portion of the auto fluorescence emitted by the tissue (); and/or c1) a portion of the remitted excitation light at the first wavelength range, and c2) a portion of the remitted light at a second wavelength range; and a control unit (), the control unit () operating the light source () and detection unit (). The present invention is further directed to a method for quantitative measurement of a fluorescent blood analyte in tissue ().

Apparatus and method for fluorescence measurements on tissue for the determination of blood fluorophores

An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.

Measurement of a fluorescent analyte using tissue excitation

Exemplary embodiments of system, method and computer-accessible medium can be provided in accordance with the present disclosure can be provided for generating a plurality of images associated with at least one anatomical structure using magnetic resonance imaging (MRI) data. For example, using such exemplary embodiments, it is possible to obtain at least one multi-echo fast spin-echo (FSE) pulse sequence based on the MRI data, which can include, e.g., hardware specifications of the MRI system. Further, it is possible to generate each of the images based on a particular arrangement of multiple echoes produced by the multi-echo FSE pulse sequence(s).

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New York, NY, United States of America

Gary M Brittenham