Life Technologies Corporation

Applera Corporation

Applied Biosystems, LLC

Gillette Canada Company

The Gillette Company

Pe Corporation (ny)

Gary Lim

Jacob K Freudenthal

Gary L Bordenkircher

Mark F Oldham

Donald R Sandell

Max K Yoshimoto

Jon A Hoshizaki

John S Shigeura

Zbigniew T Bryning

Sean Matthew Desmond

Adrian Fawcett

Kevin S Bodner

Mark Borodkin

Mark Edward McConnell

Todd A Weinfield

Ronald Danehy

Declan Connolly

Jeff Hoefer

Joseph Watson

David George Grau

Niall O'Gara

Robert Anthony Walsh

Dustin R Brown

Kevin Albert Maher

Michael C Pallas

James C Nurse

Eliodor G Ghenciu

John Dixon

Theodore E Straub

Jorge Fonseca

Evan Foster

Kuan Moon Boo

Chee Kiong Lim

Francis T Cheng

David M Liu

Alexander V Dukhovny

Soo Yong Lau

Woon Liang Soh

Victor H Yee

David Fortescue

Ming Shen

Gary A Chappell

Peng Li

Ming Song Chen

Ruoyun Wu

Geoffrey Dahlhoff

Yan Feng

Ted Straub

Thiam Chye Lee

Jeff Dere

Bin Cao

Kirk Hirano

David Liu

Theodore Straub

A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.

Systems and methods for biological analysis

A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.

Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.

Microfluidic size-exclusion devices, systems, and methods

A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/&#x2212;15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.

Systems and methods for loading liquid samples

A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.

A multi-well microfiltration apparatus and method are provided and feature a manual touch-off system for transferring pendent drops hanging from discharge-conduits of a discharge-conduit array to respective receiving wells or receiving holes of a corresponding receiving array, with minimum or no cross-contamination between the discharge conduits, or the receiving wells or receiving holes. The manual touch-off is achieved by manually shifting a carriage that supports one of the arrays, into a position whereat pendent drops of fluid hanging from the distal ends of the discharge conduits contact the inner sidewalls of the corresponding receiving wells or receiving holes of the receiving array.

Manually-operable multi-well microfiltration apparatus and method

A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.

PCR sample handling device

A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the heat distribution plate, and, optionally, a heating tray can be used to receive the heat source and heat distribution plate. The heater module is adapted to engage a sample purification tray having a plurality of purification and/or discharge columns which can extend through openings in the heater module and direct a sample into a sample receiving tray. Methods of heating samples using the heater module are also described.

Sample tray heater module

Toothbrush bristle pattern

Toothbrush handle

Growing community of inventors

San Francisco, CA, United States of America

Gary Lim