Roto-finish Company, Inc.

Other

Gary L McNeil

Jeremy Paul Hammond

The present invention relates to a method and apparatus for the isolation, modification and re-administration of a molecule or biomolecule, or a class of biomolecules, from the body fluid of a mammal via an extracorporeal closed circuit device. The device is able to capture and modify the biomolecule by the covalent or non-covalent attachment of a secondary molecule or protein, by cross-linking the captured molecule, or by altering the structure of the molecule (for example, by deglycosylation, peptide cleavage, or aggregation). The apparatus can be used to return the modified molecule or biomolecule to the mammalian subject. The device and methods may be utilized for the patient-specific diagnosis and/or treatment of a disease state which presents an associated molecule or protein in plasma or any other fluidized physiological system. The methods and apparatus may also be employed as a closed system allowing the on-line purification and/or modification of a target molecule or biomolecule from a fluid source such as a bioreactor or perfusion bioreactor.

Closed-circuit device and methods for isolation, modification, and readministration of specific constituents from a biological fluid source

Closed-circuit device and methods for isolation, modification, and re-administration of specific constituents from a biological fluid source

A device for finishing workpieces, such as automobile wheels. The device includes a bowl assembly containing polishing media therein, and a drive assembly including a rotatable turret which carries the wheels thereon so that same are orbitally driven through the polishing media. A cam arrangement is provided which essentially continuously adjusts the angle of the wheels relative to the polishing media by pivoting the wheels about respective vertical axes. The device is additionally provided with a vertical drive assembly which allows vertical oscillation of the wheels relative to the media, and the polishing device also permits adjustment of the pitch or rake angle of the wheels relative to the horizontal.

Wheel polishing device

Apparatus for finishing parts or workpieces in the presence of liquid in a finishing chamber having outer upstanding wall and bottom members which are symmetrically arranged about a common axis and relatively rotatable about the axis, for imparting motion to the contents of the chamber for finishing of the parts or workpieces therein, and means for causing the relative motion, having an improved resilient seal between the bottom and the wall members in the form of a resiliently-restricted zone, comprising a partial bottom-forming lip or other partial bottom-forming element, and means for pumping fluid into said zone at a sufficient pressure so that the fluid enters the zone and then flows upwardly into the finishing chamber, is disclosed. Storage chambers below the bottom and adjacent the upstanding wall are employed for storage of fluid to be introduced into the finishing chamber. Separate drainage means for internal drainage of fluid from the finishing chamber is provided so that no drainage of fluid and 'fines' goes through the seal. In a preferred embodiment a rotatable shaft associated with a rotatable bottom is hollow and passageways are provided from interior of the finishing chamber cavity into the hollow passageway for drainage of fluid out of the apparatus. A greatly improved seal having an extended life and permitting closer tolerances, as well as closer control and more efficient maintenance of tolerances, is thereby provided. An improved method for finishing parts involving purging of the seal comprising the resiliently-restricted zone with fluid under pressure from the various aforementioned sources outside the finishing zone proper as above-described is also disclosed.

Centrifugal finishing apparatus embodying improved seal and method

Apparatus for finishing parts or workpieces in the presence of liquid in a finishing chamber having outer upstanding wall and bottom members which are symmetrically arranged about a common axis and relatively rotatable about the axis, for imparting motion to the contents of the chamber for finishing of the parts or workpieces therein, and means for causing the relative motion, having an improved resilient seal between the bottom and the wall members in the form of a resiliently-restricted zone, comprising a partial bottom-forming lip or other partial bottom-forming element, and means for pumping fluid into said zone at a sufficient pressure so that the fluid enters the zone and thence flows upwardly into the finishing chamber, is disclosed. Storage chambers below the bottom and adjacent the upstanding wall are employed for storage of fluid to be introduced into the finishing chamber. Separate drainage means for internal drainage of fluid from the finishing chamber is provided so that no drainage of fluid and 'fines' goes through the seal. In a preferred embodiment a rotatable shaft associated with a rotatable bottom is hollow and passageways are provided from interior of the finishing chamber cavity into the hollow passageway for drainage of fluid out of the apparatus. A greatly improved seal having an extended life and permitting closer tolerances, as well as closer control and more efficient maintenance of tolerances, is thereby provided. An improved method for finishing parts involving purging of the seal comprising the resiliently-restricted zone with fluid under pressure from the various aforementioned sources outside the finishing zone proper as above-described is also disclosed.

A vibratory finishing machine for the surface finishing of workpieces comprising an essentially spiral trough, having a plurality of channels in side-by-side relationship, resiliently mounted for vibration and tilted with respect to the horizontal; such a spiral trough which is employed as a finishing chamber by attachment to a resiliently-mounted vibratory structure of a vibratory finishing machine; and a method and apparatus for vibratorily finishing a workpiece by subjecting it to a surface finishing medium in such a trough, having liquid finishing medium in only lower sections thereof and having solid finishing medium in an outer channel of said trough, are disclosed.

Multistage finishing device and method

A novel method for the surface-planing of the elongated parts, in which the parts are not submerged in the finishing media, and in which the direction of the finishing media orbit is in the direction of feed or of the longitudinal dimension of the part, is disclosed, as well as novel open-top finishing machines, comprising finishing chambers having internal flow diverters, and side walls lower than front and back walls, all especially adapted for carrying out the surface-planing method of the invention.

Vibratory finishing chamber

A novel method of forming a finishing chamber by inserting a cylindrical tube into a corresponding opening in the bottom of a dished tank head having a bottom and an upwardly-extending outer wall, inserting a cone-shaped gusset or collar having an outwardly and downwardly-extending skirt and an opening in the top thereof, corresponding to the circumference of the cylindrical tube, over the tube and with its outer circumference in contact with the tank head, and welding the tube to the tank head and to the gusset and the gusset to the bottom of the tank head, thereby simply to provide the essentials of a finishing chamber, is disclosed. The outer wall of the finishing chamber may be extended by welding a sheetform annular ring to the top of the outer wall of the tank head, and the chamber may be lined with elastomer and fitted with a screen deck. The chamber itself and finishing machines embodying the same are also disclosed, and are characterized by simplicity of fabrication and structural stability of the chamber, and numerous advantages in operation which follow therefrom.

Method of producing a finishing chamber for a vibratory finishing machine

Finishing chamber and finishing machine comprising the same

A novel method for the surface-planing of elongated parts, in which the parts are not submerged in the finishing media, and in which the direction of the finishing media orbit is in the direction of feed or of the longitudinal dimension of the part, is disclosed, as well as novel open-top finishing machines, comprising finishing chambers having internal flow diverters, and side walls lower than front and back walls, all especially adapted for carrying out the surface-planing method of the invention.

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Allegan, MI, United States of America

Gary L McNeil