Elwha LLC

Kota Biotherapeutics, LLC

Somne LLC

The Invention Science Fund I LLC

Gary L McKnight

Roderick A Hyde

Lowell L Wood, Jr

Jordin T Kare

Elizabeth A Sweeney

Eric Leuthardt

Clarence T Tegreene

Tony S Pan

Michael Baym

Robert C Petroski

Wayne R Kindsvogel

Katherine E Sharadin

Edward K Y Jung

Mahalaxmi Gita Bangera

Nathan P Myhrvold

Mark A Malamud

Charles Whitmer

Michael A Smith

Muriel Y Ishikawa

Dennis James Rivet, Ii

Kenneth G Caldeira

Paul Duesterhoft

Melanie K Kitzan

Katherine A Sharadin

Jeffrey A Bowers

Daniel Hawkins

Eleanor V Goodall

Eric C Leuthardt

Michael H Baym

Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.

Compositions and methods for modified b cells expressing reassigned biological agents

Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.

Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin

An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.

Obtaining, with a sleep-apnea device, information related to sleep-apnea events and sleep-apnea treatment, and correlating sleep apnea events and sleep-apnea treatment with subject lifestyle and wellbeing

Systems and methods are described for monitoring compression applied by a compression bandage to a body portion of an individual. A system embodiment includes, but is not limited to, a deformable substrate integrated with a textile configured to conform to a body portion; a sensor assembly coupled to the deformable substrate, the sensor assembly including one or more strain gauges configured to generate one or more sense signals associated with a strain of the textile; circuitry operably coupled to the sensor assembly and configured to receive the one or more sense signals associated with the strain of the textile; and a reporter operably coupled to the circuitry and configured to generate one or more communication signals responsive to instruction by the circuitry, the one or more communication signals associated with the strain of the textile.

Systems and methods for monitoring compression with compression bandages having stretchable electronics

An embodiment of a system for treating sleep apnea includes a collar, a pump, a motor, a sensor, and a controller. The collar is configured to maintain an airway of a subject open while the subject is sleeping by applying, to a throat of the subject, a negative pressure having a magnitude, and the pump is configured to generate the negative pressure. The motor is configured to drive the pump, and the sensor is configured to generate a sense signal that is related to a degree to which the airway is open. And the controller is configured to vary the magnitude of the negative pressure in response to the sense signal. For example, one or more of the pump, motor, sensor, and controller can be secured to the collar such that the system is self-contained, i.e., the entire sleep-apnea system can be worn by the subject.

Treating sleep apnea with negative pressure

Compositions and methods for modified B cells expressing reassigned biological agents

An identification device includes, but is not limited to, a deformable substrate; a sensor assembly including one or more identity sensors configured to generate identity sense signals associated with a physical characteristic of an individual subject; circuitry configured to receive the identity sense signals, the circuitry including an identity comparison module configured to compare identity sense signals to reference data indicative of physical characteristics associated with an identity of at least one individual to determine whether the identity sense signals correspond to the identity of the at least one individual; and a reporter configured to generate communication signals associated with a comparison of the identity sense signals to reference data, the reporter including a transmitter or transceiver configured to transmit the communication signals to a system for association with a file corresponding to the at least one individual.

Systems and methods for individual identification and authorization utilizing conformable electronics

Devices and methods for profiling microbiota of skin are described which include a microbe profiling device including a device head and a hand-held housing, the device head including an epidermis-engaging component and an access window and configured to dislodge microbes from a skin surface, and the hand-held housing defining an opening aligned with the access window, the hand-held housing including a motor operably coupled to a motivatable component, a substrate disposed in relation to the motivatable component and including a microbe-capture region, a location-capture component to detect a location of one or more regions of the skin surface as the epidermis-engaging component contacts said one or more regions, at least one sensor component to detect one or more signals emitted or reflected from the microbe-capture region, and a computing component including circuitry to associate the location of said one or more regions of the skin surface and the detected one or more signals.

Devices and methods for profiling microbiota of skin

Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification.

Modifying a cosmetic product based on a microbe profile

An system includes, but is not limited to, a control system; and a device including a deformable substrate, a sensor assembly including one or more identity sensors configured to generate identity sense signals associated with a physical characteristic of an individual subject, circuitry configured to receive the identity sense signals, the circuitry including an identity comparison module configured to compare identity sense signals to reference data indicative of physical characteristics associated with an identity of at least one individual to determine whether the identity sense signals correspond to the identity of the at least one individual, and a reporter configured to generate communication signals associated with a comparison of the identity sense signals to reference data, the reporter including a transmitter or transceiver configured to transmit the communication signals to a system for association with a file corresponding to at least one of the individual subject or the device.

Devices, systems, and methods for assessing microbiota of skin are described, including: a skin-covering material including an inner surface and an outer surface, the inner surface substantially conforming to a topography of a skin surface of an individual and including a plurality of signal-generating complexes, one or more of the plurality of signal-generating complexes configured to emit one or more signals in response to at least one type of microbe; an image capture device to capture an image of the inner surface of the skin-covering material, the image including one or more signals emitted from the plurality of signal-generating complexes, and to transform the image into a digital output; and a computing device including circuitry configured to receive the digital output, compare the properties of the imaged one or more signals with a database of reference signal-generating complexes, and generate a digital spatial profile of microbes on the skin-covering material.

Systems, methods, and devices for assessing microbiota of skin

An identification device includes, but is not limited to, a deformable substrate configured to conform to a skin surface of a body portion of a healthcare provider; a sensor assembly coupled to the deformable substrate, the sensor assembly including one or more identity sensors configured to generate one or more identity sense signals associated with at least one physical characteristic of an individual subject other than the healthcare provider; circuitry configured to compare the one or more identity sense signals generated by the sensor assembly to reference data indicative of one or more physical characteristics associated with an identity; and a reporter configured to generate one or more communication signals associated with a comparison of the one or more identity sense signals generated by the sensor assembly to reference data indicative of one or more physical characteristics associated with an identity of at least one individual.

Systems and methods are described for monitoring an individual subject and facilitating a motion regimen of the individual subject. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly configured to generate one or more sense signals based on detection of at least one of a movement of the body portion or at least one physiological parameter of the body portion; a processor configured to receive the one or more sense signals, the processor including circuitry configured to identify a physiological state of the individual subject based on at least one of the movement of the body portion or the at least one physiological parameter of the body portion; and an effector operably coupled to the processor and configured to effect at least one predetermined motion of the body portion corresponding to a motion regimen responsive to control by the processor.

Monitoring body movement or condition according to motion regimen with conformal electronics

Systems and methods are described for monitoring an individual and facilitating a motion regimen of the individual. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly to generate sense signals based on detection of a movement of the body portion and a physiological parameter of the body portion during a motion regimen executed by the individual; a processor including circuitry configured to identify a pain state of the individual based on at least one of the movement or the physiological parameter, and to compare at least one of the pain state, the movement, or the physiological parameter to threshold target values; and a communicator configured to generate communication signals responsive to instruction by the processor, the communication signals associated with comparison between at least one of the pain state, the movement, or the physiological parameter to threshold target values.

Growing community of inventors

Bothell, WA, United States of America

Gary L McKnight