Medtronic, Inc.

Arteriocyte Medical Systems, Inc.

Gary L Berg

Victor D Dolecek

Kevin D McIntosh

David R Malcolm

Kenneth E Merte

Vitaly G Sitko

Jeffrey M Gillberg

Martin A Rossing

David K Peterson

Robert A Neumann

Inna A Pikulenko

William J Combs

Jeffrey David Wilkinson

Chester Gary Nelson

Charles R Stomberg

Richard M Powell

Karen A Stone

Michael R Tollinger

Vitally G Sitko

Jill H Ernst

Victor D Doleck

David Malcolm

Kevin D Mcintosh

A medical device senses cardiac electrical signals including T-waves attendant to ventricular myocardial repolarizations and detects a T-wave template condition associated with non-pathological changes in T-wave morphology. The device generates a T-wave template from T-waves sensed by the sensing circuit during the T-wave template condition. After generating the T-wave template, the device acquires a T-wave signal from the cardiac electrical signal and compares the acquired T-wave signal to the T-wave template. The device detects a pathological event in response to the acquired T-wave signal not matching the T-wave template.

T-wave morphology analysis for pathological event detection

Systems and methods are described for analyzing a plurality of beats after detection of a suspected cardiac arrhythmia to determine a beat discriminator, identify a beat subsequent to completion of charging of an implantable medical device by applying the beat discriminator, and synchronize delivery of a shock from the medical device to the identified beat. In some examples, identifying the beat using the beat discriminator may help to accurately synchronize the shock with a beat representative of physiological cardiac events instead of an oversensed beat, e.g., noise sensed signal that is misclassified as a cardiac beat.

Synchronization of electrical stimulation therapy to treat cardiac arrhythmias

A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma

A medical device communications system uses subthreshold pulses, modulated to provide relatively high speed electrical communications with inexpensive external devices connectable to a body with the implant by surface leads.

Implanted medical device/external medical instrument communication utilizing surface electrodes

A leadless fully automatic follow-up (LFAPF) device that is triggered into operation either locally or remotely is implemented extra-corporeally to access cardiac data such as ECGs stored in one or more implantable medical device (IMDs) implanted in one or more patients. A telemetry unit is used in the LFAPF to transmit and test stored data in the IMDs. The telemetry unit implements a series of adjustable commands depending on the desired level of detail of the follow-up. An alternate embodiment representing intra-corporeal use of an additional device includes cardiac data monitoring and cardioversion pulse synchronization in cooperation with another IMD such as a pacer.

Leadless fully automatic pacemaker follow-up

A method and apparatus for optimizing the performance of a rate-responsive cardiac pacemaker. A pacemaker is provided which is capable of obtaining and storing information about a patient's cardiac function and about a pacemaker's operation during a brief exercise interval. The data collected includes information about the number of cardiac events during each two-second interval of the exercise, as well as the percentage of paced events during each two-second interval. Data reflecting the output of the pacemaker's activity sensor output is also collected for each two second interval of the test. In addition, AV interval data for each cardiac cycle during the test is collected, this data being distinguished according to whether it reflects atrial-pace-to-ventricular-sense or atrial-sense-to-ventricular-sense AV intervals. The disclosed pacemaker is operable in conjunction with an external programming/processing unit, which receives the stored data after the exercise test is concluded. The data is processed and presented on the programmer screen in a manner which enables the clinician to readily assimilate it and observe the effects of hypothetical changes in rate-response programming in the pacemaker. Additionally, the clinician is able to observe the programmed AV rate adaption profiles in conjunction with the patient's actual AV performance, and compare this data with an AV profile from a typical healthy heart.

Method and apparatus for monitoring pacemaker intervals

An implantable defibrillator provided with a plurality of defibrillation electrodes, which may be reconfigured to define a plurality of defibrillation pathways. The device is capable of measuring the impedance along a selected defibrillation pathway, during delivery of an impedance pulse, and monitoring the success or failure of the pulse to accomplish defibrillation or cardioversion. In response to a detected failure to accomplish cardioversion in conjunction with a measured change of impedance of greater than a predetermined amount, a new defibrillation pathway is selected, which may employ some or all of the electrodes employed to define the original impedance pathway. The device also includes apparatus for varying the relative amplitude of defibrillation pulses applied to individual electrodes used in sequential or simultaneous, multiple electrode pulse regimens, in order to equalize current distribution, in response to measured pathway impedances.

Method and apparatus for termination of ventricular tachycardia and

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Edina, MN, United States of America

Gary L Berg