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Her Majesty the Queen in Right of Canada, As Represented by the Minister

University of Manitoba

Gary Kobinger

Heinz Feldmann

Ami Patel

Darwyn Kobasa

Shawn Babiuk

Michael Gray

Kaylie Tran

Alexander Bello

Xiaojian Yao

Zhujun Ao

We have developed a series of Ebola vims envelope glycoprotein (EboGP)-based chimeric fusion proteins that are still able to maintain an efficient EboGP-mediated virus entry in various cell types including human antigen-presenting cells (APCs) while presenting large viral polypeptides, such as HIV Env v3-v5 domain (as large as 241 aa), at the apex and the sides of each EboGP monomer to elicit robust host immune responses. This invention demonstrates the feasibility of an EboGP-based chimeric fusion technology as a novel vaccine approach against different microbial pathogens, including that in human and animals, and against cancers.

Ebola virus and Marburg virus glycoprotein mucin-like domain replacement expression system used as new vaccine approaches

Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.

Peptide adjuvants

A modified CAG promoter which is capable of driving high levels of expression of sequences of interest inserted downstream therefrom is herein described.

Optimized promoter sequence

Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.

Porcine adeno-associated viruses

Growing community of inventors

Winnipeg, Canada

Gary Kobinger