Pharmacia & Upjohn Company

Gary J Cleek

Richard Charles Thomas

Michael R Barbachyn

Donn G Wishka

Joel Morris

Stephen T Schlachter

Richard Allen Nugent

Michael J Murphy

Douglas K Hutchinson

Fritz Reusser

Hiroyoshi Yamada

David R Graber

Irene W Althaus

The present invention provides compounds of formula I ##STR1## or a pharmaceutical acceptable salt thereof wherein Q, X, Y and R.sub.1 are as defined in the claims which are antibacterial agents.

Isoxazoline derivatives useful as antimicrobials

The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I ##STR1## wherein R.sub.1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same and different and are H, F, or CH.sub.3 ; W is O, or S;

Substituted aminophenyl isoxazoline derivatives useful as antimicrobials

Alpha-substituted pyrimidine-thioalkyl and alkylether compounds as

The present invention provides compounds of formula 1 ##STR1## or pharmaceutical acceptable salts thereof wherein A and R.sub.1 are as defined in the claims which are antibacterial agents.

Pyrimidine-thioalkyl and alkylether compounds

This invention provides novel oxazolidinone derivatives represented by chemical Formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein X is NR.sub.1, CR.sub.2 R.sub.3, O, S, SO, or SO.sub.2 ; and Z is NR.sub.4, S, SO, SO.sub.2 or O. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci and streptococci, as well as anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis and Mycobacterium avium.

Oxazolidinone antibacterial agent with tricyclic substituents

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Kalamazoo, MI, United States of America

Gary J Cleek