Eli Lilly and Company

Gary G Marconi

Marvin M Hoehn

Robert L Hamill

Walter M Nakatsukasa

LaVerne D Boeck

Norbert Neuss

Manuel Debono

Milton J Zmijewski

R Michael Molloy

Robert M Logan

New glycopeptides prepared by biotransformation of a vancomycin-type antibiotic by an Acinomadura citrea culture (NRRL 18382), which are useful intermediates, and methods of preparing the biotransformed intermediates by adding a vancomycin-type glycopeptide to a growing culture of Actinomadura citrea NRRL 18382 and continuing fermentation under submerged aerobic conditions, are provided.

Biotransformation of glycopeptide antibiotics

The novel glycopeptide antibiotic A-51568B is produced by submerged, aerobic fermentation of Nocardia orientalis NRRL 15232. A-51568B demonstrates antibiotic activity against gram-positive bacteria.

A-51568B antibiotic

Antibiotic A-51568 is produced by submerged, aerobic fermentation of new Nocardia orientalis NRRL 15232. The antibiotic is effective against gram-positive organisms.

Process for producing antibiotic A-51568 by fermentation and

Process for production of A-51568B antibiotic

Antibiotic A51568 is produced by submerged, aerobic fermentation of new Nocardia orientalis NRRL 15232. The antibiotic is gram-positive.

A51568 Antibiotic and process for producing thereof

Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants.

Process for producing deoxynarasin antibiotics

Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants. 20-Deoxynarasin and its salts are cardiotonic agents.

Deoxynarasin antibiotics

Antibiotic A-32390 complex, comprising factor A and other structurally related factors, is produced by cultivation of Pyrenochaeta sp. NRRL 5786 under submerged aerobic conditions, and isolated by extraction of the broth. Individual A-32390 factor A is separated by chromatography. The A-32390 complex, individual factor A and acyl ester derivatives of factor A inhibit dopamine-.beta.-hydroxylase and have antifungal, antibacterial, and hypotensive activity.

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Indianapolis, IN, United States of America

Gary G Marconi