The Scripps Research Institute

University of Nebraska

Gary E Siuzdak

Richard A Lerner

Dale L Boger

Howard E Gendelman

Jillian Buriak

R Lee Mosley

Steven J Henriksen

Ben Cravatt

Erica Forsberg

Jing Wei

The present invention provides novel biomarkers for regulatory T cells (Treg) function and Parkinson's disease.

Biomarkers for monitoring immune transformation

A method for desorption and ionization of an analyte from a porous, light absorbing, semiconductor is disclosed that can be used to replace conventional mass-assisted laser desorption/ionization (MALDI) in the mass spectrometry of proteins and biomolecules. The process uses the semiconductor to trap an analyte on the semiconductor. The semiconductor is illuminated by a light source and absorbs the light energy. The semiconductor then uses the light energy is to desorbed and ionize the analyte. The analyte so desorbed and ionized is suitable for detection by mass analyzers.

Desorption/ionization of analytes from porous light-absorbing semiconductor

Sleep may be induced by administration of fatty acid primary amides, including cis-9,10-octadecenoamide. Furthermore, sleep deprivation may be assayed by analyzing cerebrospinal fluid with respect to the presence of fatty acid primary amides, including cis-9,10-octadecenoamide. The presence of cis-9,10-octadecenoamide in cerebrospinal fluid is correlated with comparative sleep deprivation.

Method for sleep induction

Growing community of inventors

San Diego, CA, United States of America

Gary E Siuzdak