Bayer Corporation

Siemens Healthcare Diagnostics Gmbh

Gary E Rehm

Michael J Pugia

Paul F Corey

Willis E Howard, Iii

Steven W Felman

Marilyn J Radtke

Gerald H Shaffer

Willis Howard

Richard Hurtle

David Hough

Willis E Howard

Marilyn Radtke

A method and apparatus for using an infrared reading to detect the misidentification of a diagnostic test strip disposed on a feed table comprising the steps of determining if the test strip possesses specified reagents, reading the infrared reflectances from the reagent positions, determining if the reflectances are within an acceptable predetermined range and aborting the test if the infrared reflectances are not within the acceptable predetermined range.

Method and apparatus for using infrared readings to detect misidentification of a diagnostic test strip in a reflectance spectrometer

Disclosed is an assay for determining the presence and concentration of trypsin inhibitor in urine samples. The assay reagents, which may be used either in the liquid or dry states, include trypsin, a trypsin substrate and a polycarboxylic chelating agent. The inclusion of the chelating agent in the assay has been found to reduce variation in the assay results.

Urinary trypsin inhibitor assay containing a chelating agent

A compound of the formula (I)wherein Ris a protecting group for N&#x3b1;, Ris a protecting group for N, and Ris aryl, and wherein the compound of formula (I) is a trypsin substrate such that trypsin cleaves the O&#x2014;C single bond, which liberates R&#x2014;OH; a diagnostic device comprising same; a method for preparing the diagnostic device; and a method of using the diagnostic device to detect levels of urinary trypsin inhibitor in a biological sample; and a diagnostic kit for detecting levels of urinary trypsin inhibitor in a biological sample.

Trypsin substrate and diagnostic device, and method of using same

An improved test strip for determining the presence or concentration of unknown or a constituent in a liquid test sample is disclosed. The test strip comprises a support strip and a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of interacting with the constituent of interest to produce a detectable or measurable response. The test strip further comprises an infrared dye, applied either to the support strip or incorporated into a test pad, which ensures proper alignment of the test strip in an apparatus having a detection system for the detectable or measurable response. The improved test strip reduces the number of erroneous assays for the constituent of interest.

Test strip for the assay of an analyte in a liquid sample

An apparatus for automatically detecting the presence of a reagent strip (,) having a body fluid sample disposed thereon and for inspecting the reagent strip (,) after the presence of the reagent strip (,) is detected is provided with a detection system adapted to automatically detect the presence of a reagent strip (,) at a reagent strip receiving area (,), a light source (,or,) adapted to illuminate the reagent strip (,) after the presence of the reagent strip (,) at the reagent strip receiving area (,) is detected, and a detector (,or,) adapted to receive light from the reagent strip (,) when the reagent strip (,) is being illuminated by the light source. The detection system is provided with a light emitting apparatus (,) adapted to illuminate the reagent strip receiving area (,), a detecting apparatus (,) adapted to receive light from the reagent strip receiving area (,) while the reagent strip receiving area (,) is being illuminated by the light emitting apparatus (,) and to generate a detection signal relating to the amount of light detected from the reagent strip receiving area (,), and a circuit (,or,) adapted to automatically determine whether a reagent strip (,) is present at the reagent strip receiving area (,) based on the magnitude of the detection signal.

Spectrophotometric apparatus with reagent strip detection

An apparatus adapted to inspect reagent strips having fluid samples, such as urine samples, disposed thereon and to reduce the likelihood of contamination of one of the fluid samples with another of the fluid samples is provided with a reagent strip support (,) adapted to support a reagent strip (,) having a plurality of reagent pads (,) disposed in a longitudinal direction along the reagent strip (,), including reagent pad which has a reagent sensitive to contamination. The apparatus also includes a reagent strip mover (,and/or,) adapted to cause the reagent strip (,) to be moved in a direction generally transverse to the longitudinal direction from an initial reagent strip location to an inspection location (,or,), a light emitter (,or,) adapted to illuminate the reagent strip (,) when the reagent strip (,) is supported by the reagent strip support (,and/or,) at the inspection location (,or,), and a detector (,or,) adapted to receive light from the reagent strip (,) when the reagent strip (,) is being illuminated by the light emitter (,or,).

Spectrophotometric apparatus for reducing fluid carryover

An apparatus for inspecting a reagent strip (,) having a fluid sample disposed thereon is provided with a conveyor system (,) adapted to move the reagent strip (,) from a first reagent strip inspection location to a second reagent strip inspection location, a first readhead (,) associated with the first reagent strip inspection location, and a second readhead (,) associated with the second reagent strip inspection location. Each of the readheads (,) has a light source (,) and a light detector (,) associated therewith, each light source (,) being adapted to illuminate the reagent strip (,) at one of the reagent strip inspection locations and each light detector (,) being adapted to detect light from the reagent strip (,) when the reagent strip (,) is disposed at one of the reagent strip inspection locations.

Spectrophotometric apparatus with multiple readheads

An apparatus for analyzing a body-fluid sample, such as a urine sample, disposed on a reagent pad is provided with means for illuminating the reagent pad on which the body-fluid sample is disposed, means for detecting light received from the reagent pad and generating a first reflectance signal at a first time and a second reflectance signal at a second time, and means for assigning a color to the body-fluid sample based upon the magnitudes of the first and second reflectance signals. The means for assigning the color to the body-fluid sample may include means for determining a pair of color coefficients each of which has a magnitude based upon the magnitudes of the reflectance signals and means for assigning the color to the body-fluid sample based upon the magnitudes of the color coefficients.

Apparatus and method for determination of urine color

An apparatus for analyzing a body-fluid sample disposed on a reagent pad is provided with a light bulb for successively illuminating a plurality of different portions of the reagent pad on which the body-fluid sample is disposed and a detector array for detecting light received from the reagent pad and generating a plurality of reflectance signals in response to light received from a corresponding one of the different portions of the reagent pad. The apparatus is also provided with means for determining whether the magnitude of one of the reflectance signals is substantially different than the magnitude of another of the reflectance signals. Where the body-fluid sample is urine, this capability allows the apparatus to detect the presence of non-hemolyzed in the urine sample. The light bulb may successively illuminate a plurality of overlapping portions of the reagent pad, and may successively illuminate at least three different portions of the reagent pad which are linearly offset from each other.

Growing community of inventors

Elkhart, IN, United States of America

Gary E Rehm