Abbott Laboratories Corporation

Gary E Katz

Marc L Masor

Matthew A Kuchan

Chron-Si Lai

John D Benson

Debra L Ponder

Jeffrey M Boff

Paul W Johns

Marti S Bergana

Robin J Halter

Christine L Clinger

Christopher T Cordle

Melinda Guzman-Harty

John B Lasekan

David R Wolf

Mustafa Vurma

William T Malone

Douglas Gene Bynum

Julia A Byard

This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

Infant nutritional product with RRR alpha-tocopherol

Disclosed are concentrated liquid human milk fortifiers including extensively hydrolyzed casein and a stabilizer system. The stabilizer system includes an OSA-modified corn starch in combination with a low acyl gellan gum. In one embodiment, the concentrated liquid human milk fortifier is hypoallergenic and includes extensively hydrolyzed casein as the sole protein source in combination with the OSA-modified corn starch and low acyl gellan gum.

Stable concentrated liquid human milk fortifier

Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Nutritional products including a novel fat system including fatty acids

Disclosed are compositions comprising carbohydrate; lipid, comprising from about 0.25% to about 2.5% lecithin by weight of total lipid; from about 90% to about 99.5% of intact protein by weight of total protein; and from about 0.5% to about 10% of at least one hydrolyzed protein selected from the group consisting of hydrolyzed casein protein and hydrolyzed whey protein; wherein the hydrolyzed protein has a degree of hydrolysis of between about 23% and about 90%, and wherein the compositions are nutritional powders. The nutritional powders provide improved oxidative stability and sensory performance.

Stable nutritional powder

Disclosed are compositions comprising carbohydrate; lipid, comprising from about 0.25% to about 2.5% lecithin by weight of total lipid; from about 0.5% to about 10% hydrolyzed casein protein by weight of total protein; and from about 90% to about 99.5% intact protein by weight of total protein; wherein the compositions are nutritional powders. The nutritional powders provide improved oxidative stability and sensory performance.

Disclosed are nutritional powders, including lactose-free powders or other oxidatively sensitive nutritional powders, comprising at least about 400 ppm by weight of ascorbyl palmitate, preferably in combination with at least about 300 ppm by weight of cystine, cysteine, or combinations thereof. It has been found that these powders, especially the lactose-free embodiments, have improved stability as measured by sensory performance and reduced vitamin A degradation during prolonged storage.

Stable nutritional powder containing ascorbyl palmitate

The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closely resembling the breast-fed infant.

Infant formula and methods of improving infant stool patterns

The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closley resembling the breast-fed infant.

An improved enteral nutritional formula containing ribo-nucleotide equivalents (RNA, mono-, di- and triphosphate nucleotides, nucleosides and adjuncts such as activated sugars) at a level of at least 10 mg/100 Kcal (kilocalorie) of formula is disclosed. The formula comprises carbohydrates, lipids, proteins, vitamins and minerals and four (4) ribo-nucleotide equivalents at specific levels and ratios. The invention also discloses novel methods of production and analytical techniques. This invention also provides a dietary formula that enhances the immune system and alleviates diarrhea.

Method for the production of an enteral formula containing

A powdered nutritional product has an oil blend which contains soy oil and/or marine oil. In order to minimize oxidation of the product an antioxidant system of natural ingredients is incorporated therein. The antioxidant system is made up of ascorbyl palmitate, beta carotene and/or mixed tocopherols, and citrate.

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Columbus, OH, United States of America

Gary E Katz