Crititech, Inc.

Gary E Clapp

Jahna Espinosa

Michael Baltezor

Matthew McClorey

Joseph S Farthing

Mark D Williams

Samuel Campbell

Julia K Fischer

Jake Sittenauer

Bala Subramaniam

Charles J Decedue

Jacob M Sittenauer

Greg Johnson

Fenghui Niu

Greg S Johnson

Jahna C Espinosa

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cmand about 0.15 g/cm, and/or a specific surface area (SSA) of at least 18 m/g, 20 m/g, 25 m/g, 30 m/g, 32 m/g, 34 m/g, or 35 m/g. Methods for making and using such compositions are also provided.

Taxane particles and their use

An equipment assembly for preparing, harvesting and collecting particles is disclosed. The assembly comprises a tandem filter system with one or more high pressure filters, one or more low pressure filters and one or more collection vessel. Particles can be prepared, harvested and collected continuously, semi-continuously or in a batch-type operation. A tandem filter system and its method of use are also disclosed. Particles made with the assembly and according the instant methods are also disclosed. The assembly provides improved particle harvesting and collection over other systems and permits continuous particle formation, in particular by dispersion of a solute-containing process fluid within a supercritical anti-solvent.

Equipment assembly for and method of processing particles

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Lawrence, KS, United States of America

Gary E Clapp