University of Pennsylvania

Gary Dubin

Gary H Cohen

Roselyn J Eisenberg

Tao Peng

The invention is directed to a herpes simplex virus vaccine comprising a herpes simplex virus glycoprotein H-glycoprotein L complex. The invention is also directed to a vaccine comprising a DNA encoding a herpes simplex virus glycoprotein H-glycoprotein L complex. Also included is an antibody which specifically binds to a herpes simplex virus glycoprotein H-glycoprotein L complex and DNA encoding the same.

Soluble herpesvirus glycoprotein complex vaccine

The invention features a preparation of a soluble herpesvirus gH/gL complex, a cell encoding a soluble herpesvirus gH/gL complex, a vaccine comprising the complex and a method of immunizing a human against a herpesvirus infection using the complex. The invention further features a method of identifying antiviral compounds using a soluble herpesvirus gH/gL complex.

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West Chester, PA, United States of America

Gary Dubin