Yale University

Gary Desir

Peter Flynn

Jessica O-Rear

Abigail Hunt

Jianchao Xu

Richard A Flavell

Jeffrey Testani

Veena Rao

Pandelakis A Koni

Leonard Kaczmarek

Bryce Nelson

The present invention relates to compositions and methods for binding and detecting or measuring renalase. In one embodiment, the renalase binding molecule measures renalase amount or activity. Thus, in diseases and conditions where a measurement of renalase is beneficial, such renalase binding molecules may act as diagnostics.

Methods for measuring Renalase

The present invention relates to compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules may act as therapeutics.

Anti-renalase antibodies for the treatment and prevention of diseases and disorders

The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.

Compositions and methods to regulate Renalase in the treatment of cancer

The present invention includes compositions and methods for detecting, treating and preventing renal and pancreatic diseases and disorders.

Compositions and methods for treating and preventing pancreatitis, renal injury and cancer

The invention described herein relates to the discovery that renalase, and fragments thereof, are useful for the treatment or prevention of cardiac and renal diseases or disorders. Thus, the invention relates to compositions comprising renalase, or fragments thereof, and methods for treating and preventing cardiac and renal disease or disorders.

Compositions and methods for detecting, treating and preventing diseases and disorders

Antibody to Renalase

Compositions to regulate renalase in the treatment of diseases and disorders

The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.

Detection, isolation and uses of renalase (monoamine oxidase C)

The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.

Methods of treatment with renalase (monoamine oxidase C)

Detection, isolation and uses of renalase (monoamine oxidase c)

The present invention relates to weight control, control of body fat and food intake, and provides useful methods for treating, inter alia, obesity, diabetes and insulin insensitivity, and conditions, diseases, and disorders relating thereto. The invention also relates to methods of identifying useful compounds relating to weight loss, food intake, diabetes, and obesity, among other things, based on the discovery that inhibiting Kv1.3 activity mediates decreased food intake, weight loss, decreased body fat, increase glucose uptake, and increased insulin sensitivity, among other things.

Growing community of inventors

Woodbridge, CT, United States of America

Gary Desir