Newsouth Innovations Pty Limited

Gary David Housley

Jeremy Pinyon

Nigel Hamilton Lovell

Edward Norman Crawford

Cherylea Browne

Matthias Klugmann

Jennie M E Cederholm

Georg Von Jonquieres

An audiometric test method is provided where a noise stress test is applied to a subject, during the application of the noise stress test measuring one or more indicators reflecting a subjects purinergic hearing adaptation to noise exposure. The measured indicators are analysed to quantify degree of change and rate of change of the subjects purinergic hearing adaptation to noise exposure. An audiometric test system and audiometer configured to perform the test is also provided.

Noise-induced hearing loss susceptibility test method and test apparatus

Embodiments of the present invention provide an electroporation system comprising an electroporation probe having at least two contiguous electrodes configured to be inserted into biological tissue for electroporation treatment, and a pulse generator electrically connected to the probe and configured to drive the electroporation probe using a sequence of one or more electric pulses to cause current transmission through the probe and induce a non-uniform electric field in the biological tissue proximate the probe electrodes. Treatment tissue can be targeted by controlling the probe configuration, carrier solution characteristics and parameters of the electroporation pulse sequence to achieve predictable electroporation outcomes. This electroporation control method can also reduce potentially toxic effects of electroporation treatment.

Electroporation system for controlled localized therapeutics delivery

Provided is a method of transfecting cells of the cochlea with an agent by electroporation, and in certain embodiments using a cochlear implant to provide at least one electroporation electrode.

Method of providing agents to the cochlea

The present invention relates to improved methods for transfecting one or more cells within a target region with an agent by electroporation. The method comprises exposing one or more cells to the agent and to a close electric field created between an anode or anode array and a cathode or cathode array in the target region for sufficient time to allow at least some of the agent to enter said one or more cells.

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Connells Point, Australia

Gary David Housley