Eli Lilly and Company

Gary D Zintgraff

James M Greene

Ta Sen Chou

Sigmund A Schildcrout

An aqueous solution of sodium or potassium 2-ethylhexanoate is spray dried in a spray drier having an inlet temperature ranging from about 100.degree. C. to about 160.degree. C. and an outlet temperature ranging from 60.degree. C. to about 130.degree. C. to provide the corresponding sodium or potassium 2-ethylhexanoate having a moisture content of from about 0.5 to about 5.0 percent by weight and having improved purity and crystalline texture.

Spray drying sodium and potassium 2-ethylhexanoate

Passing a solution, buffered to a pH of from about 3.5 to about 4.5, of an alkali metal or ammonium salt of cefamandole through a bed of an adsorbent resin depending on van der Waals forces for adsorption followed by acidification to a pH of about 2.0 with a non-oxidizing inorganic acid yields pure crystalline cefamandole, which can be separated and dried, or partitioned into a preferential solvent from which crystalline sodium cefamandole can be recovered.

Growing community of inventors

Indianapolis, IN, United States of America

Gary D Zintgraff