The Medical College of Hampton Roads

Eastern Virginia Medical School

Serono Laboratories, Inc.

Ortho Pharmaceutical Corporation

Applied Research Systems Ars Holding N.v.

Duramed Pharmaceuticals, Inc.

Eastern Virginia Medical Authority

The United States of America As Represented by the Dept. of Health &

The Medical College of Hampton Road

Gary D Hodgen

Krzysztof Chwalisz

Kristof Chwalisz

Edward Wellner

Georgeanna S Jones

Howard W Jones, Jr

Daniel Kenigsberg

Daniel Grow

Robert F Williams

Maria Michejda

Audrey Philips

Menses regulation and, when desired, contraception is achieved at low doses of estrogen and progestin, which otherwise would create episodes of breakthrough bleeding and/or withdrawal amenorrhea, by periodically inducing menses with an antiprogestin.

Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception

Antiprogestin method and kit for reducing side effects associated with low dosage HRT, oral contraception and regulating menses

A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action.

Adjunctive therapy

A method of female contraception involves administering a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively. The advantages include less menstrual bleeding, less patient anemia, less total exposure to medication, higher compliance rates and more lifestyle convenience for patients.

Methods of extended use oral contraception

The treatment of an estrogen sensitive condition by the administration of a selective estrogen receptor modulator is improved by additionally administering a progestationally active compound to the recipient. The additional agent can express both progestational and androgenic activity or an androgenically active material can be employed, if desired. Additionally, clomiphene in an array of isomeric ratios (EN:ZU) can be used alone for prevention of osteoporosis, maintenance of a healthful blood lipid profile, and prevention of breast tumors, or to sustain amenorrhea.

Control of selective estrogen receptor modulators

Treatments in which a progestational corticoid active compound is administered are improved by additionally administering a selective estrogen receptor modulator.

Corticoid therapy

Ultra low dose oral contraceptives with less menstrual bleeding and

The diagnostic interpretation of mammographic films is enhanced by administering to the women undergoing the procedure an effective amount of a gonadotropin releasing hormone antagonist or other inhibitor of ovarian steroid production or action on the breast thereof and effecting the mammogram before the effect of the antagonist or other inhibitor has dissipated.

Mammography method

A method of treating an ovarian estrogen dependent condition such as endometriosis, uterine leiomyomata, PMS or DUB involving the administration of gonadotropin releasing hormone analog and the administration of antiprogestin, which will provide a therapeutic method for long term treatment without rapid loss of bone density, as occurs using GnRH analogs alone.

Treatment of ovarian estrogen dependent conditions

A regimen for the therapeutic management of a gonadal-steroid dependent condition in a mammal constitutes reducing the estrogen supply thereof by means of administration of a GnRH antagonist in an amount effective to inhibit proliferation of endometrial tissue without substantially stopping the production of endogenous estrogen. A method of determining whether the reduced estrogen supply in an individual is such that the concentration of estradiol has been suppressed to an optimized level appropriate to the therapeutic management of the gonadal-steroid dependent condition such as endometriosis in that individual by the administration of a GnRH antagonist at a given dosage level involves titering the dosage, e.g., by conducting a progesterone challenge test and optimal regimen doses of a GnRH antagonist.

Establishment of tonic ovarian estrogen secretion for extended

Minimizing progestin associated breakthrough bleeding

A method of female contraception which is characterized by a reduced incidence of breakthrough bleeding after the first cycle involves monophasicly administering a combination of estrogen and progestin for 23-25 consecutive days of a 28 day cycle in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively and in which the weight ratio of estrogen to progestin is at least 1:45 calculated as ethinyl estradiol to norethindrone acetate.

Low dose oral contraceptives with less breakthrough bleeding and

Fertilization of an oocyte is inhibited by administering a fertilizing inhibitory amount of an antiprogestin to an ovulatory mammal in an amount which is insufficient to prevent ovulation but sufficient to inhibit fertilization, while the regularity of the menstrual cycle is sustained.

Growing community of inventors

Norfolk, VA, United States of America

Gary D Hodgen