The University of British Columbia

Gary D Brayer

Stephen G Withers

Raymond John Andersen

Leslie Karen Williams

Andrew Tarling

Robert Keyzers

Xiaohua Zhang

Christina Rose Tysoe

Katherine Woods

There are provided compounds of Formula I: various compositions thereof and methods for their use in the inhibition of &#x3b1;-amylase.

Amylase inhibitor compounds, methods of their use and compositions thereof

Provided are methods, uses and pharmaceutical compositions for inhibition of mammalian alpha-amylase in a subject, with a Helianthamide peptide or a derivative thereof in a biologically effective amount. The subject in need of alpha-amylase inhibition, may have or be at risk of developing one or more of the following: Middleton syndrome; a motility disorder of the gastrointestinal tract; postprandial reactive hypoglycemia; postprandial syndrome; irritable bowel syndrome; diabetes mellitus type 1; diabetes mellitus type 2; pre-diabetes; obesity, dumping syndrome; infant dumping syndrome; polycystic ovary syndrome; steatohepatitis; and viral infection.

Mammalian glucosidase inhibitors, methods for their use and pharmaceutical compositions thereof

Particular naturally occurring glycosylated acyl-flavonols are now shown to be effective mammalian &#x3b1;-amylase inhibitors. Such compounds can be obtained from plants of the genusand the compounds are useful in controlling starch digestion such as for management of glycemia in pre-diabetic or diabetic subjects, for management of obesity or for inhibiting oral caries or plaque formation.

Alpha-amylase inhibitors: the montbretins and uses thereof

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Richmond, CA, United States of America

Gary D Brayer