The General Hospital Corporation

The Netherlands Cancer Institute

Gary B Ruvkun

J Amaranath Govindan

Scott Ogg

Frederick M Ausubel

Laurence G Rahme

Elamparithi Jayamani

Man-Wah Tan

Heidi Tissenbaum

Jason Morris

Jacqueline E Heard

Georg Jander

Allison Koweek

Koutarou Kimura

Garth Patterson

Suzanne Paradis

Eleftherios Mylonakis

Stephen B Calderwood

Jothi Amaranath Govindan

Costi D Sifri

Shalina Mahajan-Miklos

Kaveh Ashrafi

Annegien Broeks

Ronald H A Plasterk

Andrew Diener

Julia Plotnikova

Disclosed herein are compositions and methods for attenuating detoxification response and related symptoms thereof induced by translation defect. The compositions and methods herein are useful for attenuating detoxification response and/or treat related symptoms thereof in subjects comprising translation defect. The composition and methods herein are also useful for improving pharmacokinetics of a pharmaceutical compound.

Methods and compositions for inhibiting detoxification response

Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.

Compositions and methods for improving mitochondrial function

Methods and compositions comprising carotenoids for the treatment or prevention of nausea, e.g., chemotherapy-induced nausea and vomiting.

Carotenoids for treating or preventing nausea

Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.

Therapeutic and diagnostic tools for impaired glucose tolerance conditions

In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat metabolism and the development of treatments for obesity and obesity-related diseases.

Polynucleotide and polypeptide fat metabolism regulators and uses thereof

Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.

Methods of screening compounds useful for prevention of infection or pathogenicity

Disclosed are substantially pure AGE-1 polypeptides and purified DNAs, vectors, and cells encoding those polypeptides. Also disclosed are methods for determining longevity and isolating antagonists using the AGE-1 sequence.

AGE-1 polypeptides and related molecules and methods

Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors.

Growing community of inventors

Newton, MA, United States of America

Gary B Ruvkun