Evonik Corporation

Tepha, Inc.

Other

Edge Therapeutics, Inc.

Gary Anthony Winchester

Peter Markland

David P Martin

Thomas R Tice

Kevin Burton

R Loch Macdonald

Cara R Davis

Angela R Stella

Parissa Heshmati

Thomas Robert Tice

Compositions and methods of making and using of microparticle compositions that provide faster flow or improved injectability through smaller or small-diameter needles have been developed. Notably, the microparticle compositions can be successfully delivered or administered through smaller-diameter needles than other microparticle compositions prepared from biocompatible or biodegradable polymers including, for example, poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate. The microparticle compositions can exhibit a higher solids loading for a given needle size and/or faster flow through needles than other microparticle compositions. Further, blending or mixing the polymer of the microparticle composition with other polymer formulations can enhance the injectability of the resulting formulation.

Injectable delivery of microparticles and compositions therefor

The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles.

Emulsion-based process for preparing microparticles and workhead assembly for use with same

The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.

Polymorph compositions, methods of making, and uses thereof

Injectable delivery of microparticles and compositions therefore

Growing community of inventors

Dora, AL, United States of America

Gary Anthony Winchester