Sionex Corporation

The Charles Stark Draper Laboratory, Inc.

Shimadzu Corporation

Dh Technologies Development Pte. Ltd.

Hamilton Sundstrand Corporation

Rapiscan Systems, Inc.

Arrowhead Center, Inc.

University of Delaware

Research Corporation Technologies, Inc.

Gary Alan Eiceman

Raanan A Miller

Erkinjon G Nazarov

Evgeny Krylov

John A Wright

Lawrence A Kaufman

Hermann Wollnik

David B Wheeler

Anthony D Bashall

Cristina E Davis

Angela M Zapata

Quan Shi

Boris Tadjikov

Douglas B Cameron

Benjamin D Gardner

Hartwig Schmidt

C James Morris

Stefan R Lukow

Stephen D Kendig

Jennifer J Randall

Alexandre Tarassov

Gyoungil Lee

Dimitrios Papanastasiou

Stephen J Davila

Alexander Semenovich Tarassov

Stephen L Coy

Murray V Johnston

Hsien-Chi W Niu

Evgeny Krylova

Erikinjon G Nazarov

Peter Fowler

Derek A Lake

Craig S Leasure

An apparatus for detecting a substance comprising a direct analysis in real time apparatus; a neutral excluder; a mass spectrometer; and a vessel in. The apparatus may also comprise a separator, a gas, an alcohol, a filter, and a pump. The apparatus may also comprise electrodes in communication with the direct analysis in real time apparatus and the neutral excluder. A method for detecting a substance comprising contacting the substance with a direct analysis in real time apparatus ion stream; forming an ion and a neutral particle; flowing the ion and the neutral particle into a neutral excluder; contacting the ion and the neutral particle with a gas; and flowing the ion into a mass spectrometer.

Apparatus and method for agricultural contaminant detection

An ion-mobility spectrometer system includes a housing with an upstream end, a downstream end, and a drift region defined along a longitudinal axis through the housing between the upstream and downstream ends. A first ionizer is operatively connected the housing to supply ions at the upstream end. A second ionizer is operatively connected to the housing to supply ions at the upstream end, wherein the first and second ionizers are both situated upstream of the drift zone relative to an ion flow path through the drift zone. An electric field generator is operatively connected to the housing to drive ions through the drift zone in a direction from the upstream end toward the downstream end. The second ionizer is a radioactive ionizer mounted to the housing at the upstream end positioned to direct irradiated ions into the housing.

Ionization for tandem ion mobility spectrometry

An ion mobility spectrometer for analyzing a vapor sample including a multi-ring ion source for receiving a vapor sample, wherein the multi-ring ion source includes a series of rings, wherein each ring of the multi-ring ion source includes an ionizing layer on an inner surface thereof, for charging at least a portion of the vapor sample and creating an ionized vapor sample.

Ion source for an ion mobility spectrometer

An apparatus for detecting constituents in a sample includes first and second drift tubes defining first and second drift regions, and a controllable electric field device within a fragmentation region coupled to the first and second drift tubes. The apparatus also includes a first ion shutter positioned between the first drift and fragmentation regions. The apparatus further includes a control system configured to regulate the first ion shutter, thereby facilitating injection of a selected portion of ions from the first drift region into the fragmentation region. The control system is also configured to regulate the controllable device to modify the selected portion of ions to generate predetermined ion fragments within the fragmentation region, thereby facilitating injection of a selected portion of the predetermined fragmented ions into the second drift region. A method of detecting constituents in a sample is facilitated through such an apparatus.

Apparatus for detecting constituents in a sample and method of using the same

An ion mobility spectrometer having an ion source for generating ions; an ion detector for recording ions, and a number of substantially flat diaphragm electrodes arranged substantially perpendicular to a straight system axis that passes through the apertures in said diaphragms, with the diaphragms being arranged in a series of cells with each cell including an entrances and an exit diaphragm and a short region in between. The exit diaphragm of one cell is identical to the entrance diaphragm of the next cell, and the cells of said ion mobility spectrometer are grouped into three parts: an ion-beam forming region, an ion analyzing region, and a decelerating ion gate.

Ion-mobility spectrometer including a decelerating ion gate

A filter for a mass- or mobility-spectrometer that bars gases or vapors of a high-pressure ion source, as well as ions of high mobility and charged droplets, from entering an evacuated mass spectrometer or a mobility spectrometer at a lower pressure than the filter. The buffer gas of the high pressure ion source is blown into the volume of this filter directly or through tubes from where buffer gas and embedded ions are sucked through the aperture of a diaphragm or through an aperture of a capillary mainly from an 'extraction volume' filled with a separately supplied clean gas, into which ions of interest are pushed by electric fields formed by electrodes that are substantially rotational symmetric around the 'extraction volume' and a substantially flat electrode with respect to an axis of ion extraction and the end of the capillary and the end of a coaxial tube surrounding the capillary.

Curtain gas filter for mass- and mobility-analyzers that excludes ion-source gases and ions of high mobility

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification.

Methods and apparatus for enhanced ion based sample detection using selective pre-separation and amplification

A ion mobility-based analyzer system including a first ion mobility-based filter for passing selected ions through a time-varying field where the time-varying field being compensated by an adjustable compensation setting. The analyzer also includes a second ion mobility-based filter for receiving a first portion of ions from the first ion mobility-based filter. The second ion mobility-based filter includes a voltage gradient for separating ions of the first portion of ions where the ions have associated retention times based on their times of flight through the voltage gradient. The second ion mobility-based filter includes a detector for detecting the ions at their retention times. The analyzer system further includes a display that displays the detected ions in a plot relating the retention times of the ions in the second ion mobility-based filter with compensation settings of the first ion mobility-based filter.

Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations

A method for differential mobility separation of ions using digital-drive based high voltage fast switching electronics. The digital waveform delivered to the spectrometer is characterized by at least two substantially rectangular pulses of different amplitude and polarity. The control circuitry allows for waveform frequency, duty cycle and pulse amplitudes to be varied independently. Balanced as well as unbalanced asymmetric waveforms can be designed for optimum differential mobility separation of ions. The digital drive is designed for differential mobility spectrometers including parallel plate and segmented plate multipoles of planar symmetry, as well as multipoles of cylindrical symmetry, which may optionally be arranged in series. The use of the digital drive establishes alternating electric fields during which the displacement as a result of ion oscillation is determined by mobility coefficients.

Method and apparatus for digital differential ion mobility separation

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using multiple detection and analytical techniques in combination.

Methods and apparatus for enhanced sample identification based on combined analytical techniques

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.

Explosives detection using differential mobility spectrometry

Growing community of inventors

Las Cruces, NM, United States of America

Gary Alan Eiceman