Biocompatibles UK Limited

Worldwide Medicaltechnologies, LLC

Ideamatrix, Inc.

Other

Memorial Sloan Kettering Cancer Center

Gc Medtech LLC

Eckert & Ziegler Bebig S. A.

Eckert & Ziegler Debig S.a.

Edge Medical, LLC

Gary A Lamoureux

Richard A Terwilliger

Scott L Jahrmarkt

Warren Johnston

Warren Rice

Matthew Bouffard

James Matons

Gil'ad N Cohen

Karyn Goodman

Lino Costantini

Juan-Carlos Diaz

Colin M Carpenter

Anthony Viselli

Paul Walker

Edward Bleich

Milan J Keklak

An apparatus for providing treatment to at least one tissue includes a distal balloon, a proximal balloon, and at least one intermediate balloon positioned between the distal balloon and the proximal balloon and inflatable independently from the distal and proximal balloons. A source lumen is positioned within at least the intermediate balloon receives a radiation source to treat target tissue adjacent the intermediate balloon.

Internal body cavity therapeutic applicators and methods for using them

An apparatus for providing at least one treatment to at least one tissue having a first structural arrangement configured to expand a first portion at a distal end of the apparatus, a second structural arrangement configured to expand a second portion at the distal end and at least one lumen associated with at least one of the first structural arrangement and/or the second structural arrangement. The first structural arrangement and/or the second structural arrangement can be configured to position the at least one lumen at a particular position with respect to the tissue. A tip is configured to aid in the insertion of the apparatus into the tissue(s).

Internal body cavity therapeutic applicator arrangements and methods for using the same

A spacer for use in brachytherapy, and radiotherapy, is formed of an encapsulating material in a generally cylindrical or elongated shape. Regions are formed within the spacer and retaining therapeutic loads, such as radiation sources and/or pharmaceutical therapeutic loads, and/or other substances to treat a patient, such as drug liquids, powder or particles (e.g., microparticles or nanoparticles), with the particles or powders combined with binders, such as polyacrylamide, that are selected to gradually disperse the powder or particles at a desired rate. Such regions can be formed at various locations within the spacer, and can have various shapes depending on the particular design and intended usage. The outer surface of the encapsulating material can optionally include one or more fins, ribs or other physical protuberances or features that improve the fixity of the spacer when implanted within a patient's body.

Spacers for use in brachytherapy, radiotherapy, and other medical therapy

A brachytherapy implant includes a plurality of protrusions to reduce a tendency of the implant to migrate and rotate within a patient's body after implantation. Embodiments of the present invention are directed to spacers that resist migration and rotation. This abstract is not intended to be a complete description of the invention.

Implants including spacers for use in brachytherapy and other radiation therapy that resist migration and rotation

A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged. Another embodiment includes wings that selectively extend from an implant preventing movement of the implant.

Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy

A spacer for use in brachytherapy, and radiotherapy, is formed of an encapsulating material in a generally cylindrical or elongated shape. Regions are formed within the spacer and retaining therapeutic loads, such as radiation sources and/or pharmaceutical therapeutic loads, and/or any other substances to treat a patient, such as drug liquids, powder or particles (e.g., microparticles or nanoparticles), with the particles or powders combined with binders, such as polyacrylamide, that are selected to gradually disperse the powder or particles at a desired rate. Such regions can be formed at various locations within the spacer, and can have various shapes depending on the particular design and intended usage. The outer surface of the encapsulating material can optionally include one or more fins, ribs or other physical protuberances or features that improve the fixity of the spacer when implanted within a patient's body.

A therapeutic strand implant, for use in brachytherapy and deliverable to an implant site by way of a needle, includes a plurality of radioactive sources, and a polymeric material molded to encapsulate the radioactive sources. A space is defined by the polymeric material between each adjacent pair of the radioactive sources. A plurality of protrusions is defined by an outer surface of the encapsulating polymeric material.

Implants for use in brachytherapy and other radiation therapy that resist migration and rotation

In an embodiment, a brachytherapy device includes a cartridge adapted for use with a brachytherapy applicator. A plurality of therapeutic members are stacked parallel to one another within the cartridge. Each therapeutic member includes a radioactive seed that is at least partially encapsulated by a polymeric material. Additionally, each therapeutic member can include at least one protrusion on an outer surface of the encapsulating polymeric material to reduce a tendency for the therapeutic member to migrate and rotate within a patient's body after the therapeutic member is implanted.

Cartridge for use with brachytherapy applicator

A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.

Therapeutic member including a rail used in brachytherapy and other radiation therapy

In an embodiment a therapeutic member includes a solitary radioactive seed. The seed includes a metallic housing with radioactive material contained within the metallic housing. The metallic housing has a first longitudinal end and a second longitudinal end and a longitudinal length between the first and second longitudinal ends. A polymeric material is molded to completely and monolithically encapsulate the metallic housing of the solitary radioactive seed. The implantable therapeutic member is adapted to be implanted into patient tissue using a hollow needle. A portion of the molded polymeric material extends from one of the first and second longitudinal ends of the metallic housing to reduce a tendency of the seed to migrate and rotate within a patient's body after implantation of the member. The portion of the molded polymeric material, that extends from one of the first and second longitudinal ends of the metallic housing, causes the implantable therapeutic member to have a longitudinal length that is greater than the longitudinal length of the metallic housing.

A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and longitudinally flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands at the patient's bedside. The delivery system and method further customize the member based on a prescription.

Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings

In an embodiment, an implantable marker, which is adapted to be implanted into patient tissue using a hollow needle, includes a marker body including a radiopaque material and a polymeric material that encapsulates at least a portion of the marker body. In an embodiment, an outer surface of the encapsulating material includes one or more protrusions to reduce a tendency of the marker to migrate and rotate within a patient's body after implantation.

Markers for use in brachytherapy and other radiation therapy that resist migration and rotation

In one embodiment an after-loader for providing an implant to a hollow needle, the after-loader comprising a body having a distal end including a bevel for receiving a hub of a seed lock needle, and a bore therethrough for receiving a hub of a MICK&#xae; needle; a proximal end having a funnel shaped opening; a shield adapted to be provided over the body; and wherein the distal end further includes a taper along a portion of a distance from the distal end to the proximal end for providing a friction fit to a shield. This abstract is not intended to be a complete description of the invention.

Growing community of inventors

Woodbury, CT, United States of America

Gary A Lamoureux