Aclaris Therapeutics, Inc.

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Biomed Valley Discoveries, Inc.

Vertex Pharmaceuticals, Inc.

Gary A Decrescenzo

Edward Hellriegel

Walter Smith

Heidi Hope

David Gordon

Dimiter Stanchev Dimitrov

Zhongyu Zhu

David R Anderson

Saurabh Saha

Benjamin Joseph Littler

Ali Keshavarz-Shokri

Petinka I Vlahova

Rossitza Gueorguieva Alargova

Dean Welsch

Irina Nikolaevna Kadiyala

Xiaoyan Michelle Zhang

Brad St Croix

Alexander Aronov

Kathy Stavropoulos

Enrique Zudaire

John Robert Springer

Jeffrey James Roix

Bradley St Croix

Alexander N Scangas

Steven Seaman

Ekaterina V Albert

Jon G Selbo

Emily M Rigsbee

Stephan Xm Boerrigter

The present disclosure provides deuterated pyridinone-pyridinyl compounds and compositions useful in the treatment of p38 MAP Kinase mediated having the structures of Formula (I); wherein the A, B, and R groups are as defined in the detailed description. Methods of inhibition of p38 MAP Kinase activity in a human or animal subject are also provided.

Deuterated MK2 pathway inhibitors and methods of using the same

The present disclosure provides methods of synthesizing a compound of Formula (P)-I. The method proceeds through several different pathways including several novel chiral separations, a Sonogashira coupling, a zinc mediated reductive cyanation, as well as through various halide containing intermediates. Also disclosed is the multi-kilogram preparation of several novel intermediates.

Methods of synthesizing substituted pyridinone-pyridinyl compounds

The present disclosure relates to oral compositions of Compound I or a derivative thereof. Methods of use for treating an inflammatory condition are also disclosed.

Oral compositions of MK2 pathway inhibitor for treatment of immune conditions

Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.

Anti-CD276 antibodies (B7H3)

Growing community of inventors

Parkville, MO, United States of America

Gary A Decrescenzo