Johns Hopkins University

Genzyme Corporation

Esoterix Genetic Laboratories, LLC

Gary A Beaudry

David Sidransky

Jin Jen

Stephen L Madden

Arthur H Bertlesen

Bert Vogelstein

Michael I Sherman

Arthur H Bertelsen

The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.

Methods for the diagnosis and treatment of lung cancer

Vectors and vector systems are embodied that include a gene encoding a tumor suppressor protein. In one embodiment, the vector includes a gene encoding a tumor suppressor protein and an inducible promoter controlling the gene encoding a tumor suppressor protein. The tumor suppressor protein may be p53 protein. In another embodiment, there is provided a vector system which comprises a first vector including a gene encoding a tumor suppressor protein, and a second vector containing a nucleic acid sequence encoding an antisense sequence complementary to all or a portion of the gene encoding a tumor suppressor protein. In yet another embodiment, there is provided a vector system which comprises a first vector including a gene encoding a tumor suppressor protein, and a second vector containing a gene which encodes a protein which binds to, and thereby inhibits, the tumor suppressor protein. Such vectors and vector systems enable cells transformed thereby to continue to proliferate such that adequate amounts of infectious viral particles, generated from viral vectors including a gene encoding a tumor suppressor protein, can be harvested for administration to patients.

Vectors and vector systems including genes encoding tumor suppressor

Growing community of inventors

Nutley, NJ, United States of America

Gary A Beaudry