Cetus Corporation

Novartis Animal Health, Inc.

Gary A Anderson

Michael V Doyle

Jack H Nunberg

Thomas J White

Arthur D Newell

Douglas L Stine

Adrian Liem

The present invention relates to a method of producing a vaccine for the prevention of bacterial infections, comprising isolating the bacteria from a bovine species, growing the bacteria in a suitable growth medium for a period equal to between about 10 hours and about 18 hours so as to achieve a bacterial population equal to at least 1&times;10 CFU/ml, terminating the growth, and using a whole cell culture to form the vaccine. Additionally, the present invention relates to the vaccine comprised of a killed whole cell population of the bacteria taken from a bovine. The present invention further relates to a method for preventing footrot and liver abscesses caused by bacteria.

Fusobacterium necrophorum vaccine and method for making such vaccine

Methods for enhancing the immune response to vaccination in animals, including humans, comprise administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days post-vaccination. In addition, compositions for enhancing the immune response of an animal to a vaccine employ IL-2 as an active ingredient, preferably human IL-2.

Human IL-2 as a vaccine adjuvant

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Bucyrus, KS, United States of America

Gary A Anderson