Purdue Research Foundation

Kumamoto University

Endocyte, Inc.

National University Corporation Kumamoto University

Garth L Parham

Christopher Paul Leamon

Arun K Ghosh

Iontcho Radoslavov Vlahov

Hiroaki Mitsuya

Chun-Xiao Xu

Philip Stewart Low

Joseph Anand Reddy

Melissa Nelson

Marilynn Vetzel

Christina M Dircksen

Qingshou Chen

Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.

Compounds for positron emission tomography

The disclosure provided herein pertains to CCK2R-drug conjugates. In particular, the disclosure pertains to CCK2R-drug conjugates that target the delivery of drugs to a mammalian recipient. Also described are methods of making and using CCK2R-drug conjugates.

CCK2R-drug conjugates

Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described.

Fused tricyclic ether carbamates and their use

Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are described. Methods of using the disclosed compounds for treating patients infected with HIV are also described.

Growing community of inventors

Largo, FL, United States of America

Garth L Parham