Griffin Analytical Technologies, L.l.c.

Flir Detection, Inc.

Griffin Analytical Technology, L.l.c.

Garth E Patterson

Mark Gregory

James Mitchell Wells

Dennis Barket, Jr

John W Grossenbacher

Jason Springston

Brent Rardin

Brent Knecht

Matthew Briscoe

Anthony J Cochran

Person-portable mass analysis instrumentation configured to perform multidimensional mass analysis is provided. Mass analysis instrumentation can include a housing encompassing components of the instrumentation with the housing of the instrumentation defining a space having a volume of equal to or less than about 100,000 cm. Instrument assemblies are also provided that can include a housing coupled to an instrument component isolation assembly, wherein the component isolation assembly is isolated from an environment exterior to the housing. Exemplary instrument assemblies can include at least first and second components configured to provide analysis with a housing of the instrument at least partially encompassing the first and second components and the first component being rigidly affixed to the housing. An isolation assembly can also be provided that is rigidly affixed to the second component with the isolation assembly being isolated from received inputs of the housing.

Analytical instruments, assemblies, and methods

A sample analysis apparatus () includes processing circuitry () coupled to a data set device () and a storage device () to acquire one data set from an analysis component () according to one analysis parameter set and to prepare another analysis parameter set using another previously acquired data set.

Analytical instrumentation, apparatuses, and methods

In one implementation, an analysis device operational method includes providing a plurality of levels of programming abstraction corresponding to programming of an analysis device configured to analyze a sample, receiving input data corresponding to one of the levels of programming abstraction, processing the input data to generate analysis control data, and implementing an operation with respect to analysis of the sample using the analysis control data.

Analysis methods, analysis device waveform generation methods, analysis devices, and articles of manufacture

The present invention relates to devices for collecting and storing chemical samples and transferring those samples to analytical devices for analysis. In one implementation the device includes an interface for transferring samples and electrical signals. In another implementation, the device includes an analytical device having an interface for transferring samples and electrical signals with a sampling device. In another implementation, the device includes a sampling device having an interface for transferring samples and electrical signals with an analytical device.

Interface port for connection of a sampling device to an analytical instrument

Gas chromatography apparatuses are provided that can include a housing configured to substantially envelop the column within the compartment. Analytical instruments are provided that can include at least one chromatography column compartment having a volume of the less than 100 mL. Analytical methods are provided that can include increasing the temperature of a chromatography column at a rate of about 60&#xb0; C./minute using less than about 40 W. Methods are also provided that include providing at least one gas chromatography column compartment configured to substantially envelop a gas chromatography column and performing analysis with the one compartment in the first operable position and/or transitioning portions to the second operable position to allow access to the one compartment. Production processes are provided that can include forming a first trench within the first surface of a substrate and/or aligning the first substrate with a second substrate to define at least one compartment between the first and second substrates.

Analytical instrumentation and processes

The present invention discloses a portable sampler for collecting an atmospheric sample. In one implementation, the portable sampler includes a portable housing with an interior portion; a sample inlet communicating between an area outside the housing and the interior portion of the housing; a sample cartridge in fluid communication with the sample inlet and adapted to store the atmospheric sample, the sample cartridge being removably secured within the housing; a pump disposed within the housing and in fluid communication with the sample inlet, the pump being arranged to draw the atmospheric sample from the area outside the housing into the sample cartridge through the sample inlet; and a carrier gas inlet communicating between the area outside the housing and the sample cartridge, the carrier gas inlet being configured to couple with a carrier gas source for sweeping the atmospheric sample from the sample cartridge into an analyzer while the sample cartridge is secured within the housing.

Apparatus and method for mobile collection of atmospheric sample for chemical analysis

The present invention provides a method and system for collecting and storing an atmospheric sample for eventual analysis, where the atmospheric sample includes a mixture of at least a matrix and an analyte. In one implementation, the system includes a housing; a sample cartridge removably attached to the housing, and a pump integrated with the housing and in fluid communication with the sample cartridge, the pump being configured to draw the atmospheric sample through the sample cartridge and to subsequently evacuate the matrix from the sample cartridge. The sample cartridge includes a low thermal mass cylinder with a first end and a second end; an inlet port with a gas-tight inlet valve at the first end of the cylinder, an outlet port with a gas-tight outlet valve at the second end of the cylinder, and a sorbent material disposed within the cylinder and adapted to trap the analyte from the atmospheric sample. In addition, the interior surfaces of the cylinder, inlet valve, and outlet valve upon which sorbent material is not disposed are chemically passive.

Apparatus and method for storage of atmospheric sample for eventual chemical analysis

In one implementation, processes for designing mass separators from a series of mass separator electric field data and processes for designing an ion trap from a range of data pairs and a mass analyzer scale are provided. Methods for producing mass separators including ion traps having Z/rratios from about 0.84 to about 1.2 are also provided. Mass spectrometers are also provided that can include mass separators in tandem with one being an ion trap having a Z/rratio between 0.84 and 1.2. The present invention also provides methods for analyzing samples using mass separators having first and second sets of components defining a volume with a ratio of a distance from the center of the volume to a surface of the first component to a distance from the center of the volume to a surface of the second component being between 0.84 and 1.2.

Mass spectrometers

Ion detection methods are provided that can include applying a first voltage between a power source and a dynode, and contacting the dynode with first ions to create a first charged species. After applying the first voltage, a second voltage can be applied between the power source and the dynode, and the dynode can be contacted with second ions to create a second charged species. Mass spectrometry instrument circuitry is also provided that can include a power source coupled to a dynode via at least one switch with the switch being operatively configured in one position to apply a first voltage between the dynode and the power source, and, in another position, configured to apply a second voltage between the dynode and the power source. Mass spectrometry analysis methods are also provided that can include detecting sorted ions using a dynode configured according to an ion detection parameter with the ion detection parameter including first and second dynode values associated with first and second time values. Methods and circuitry for portable instrumentation are also provided.

Ion detection methods, mass spectrometry analysis methods, and mass spectrometry instrument circuitry

The present invention discloses a gas chromatograph assembly. In one implementation, the assembly includes a sample injector and a guard column assembly. The guard column assembly includes a guard column connected to and downstream of the sample injector; a jacket with low thermal mass surrounding the guard column; a temperature controlled heater connected to the jacket to control the temperature of the jacket and thereby the temperature of the guard column; and an insulating housing surrounding the jacket. An analytical column is connected to and downstream of the guard column.

Guard columns for gas chromatographs and gas chromatograph-mass spectrometers

One embodiment of a mass spectrometer assembly includes a base configured to define at least a portion of a vacuum chamber volume; a mass separator component within the vacuum chamber volume; a lid coupled to the mass separator component and configured to be removably operably coupled with respect to the base; and wherein the lid is configured to be positioned in a first operable position to form a hermetical seal with the base and provide the mass separator component within the vacuum chamber volume and a second operable position wherein at least a portion of the lid is spaced from the base and the mass separator component is at least partially removed from within the vacuum chamber volume. Mass spectrometer operational methods are provided that can include at least partially removing the lid from the base, wherein the removing of the lid also at least partially removes the mass separator component from the vacuum chamber volume; and inspecting the mass separator component with the mass separator component removed from the vacuum chamber volume.

Mass spectrometer assemblies, mass spectrometry vacuum chamber lid assemblies, and mass spectrometer operational methods

Instrument assemblies including a support coupled to an active substrate are provided with the support being configured to be coupled to an interior portion of an ionization chamber. Instruments are also provided that can include a chamber being configured to contact at least a portion of a sample with an ionization species. The instruments can also include an active substrate within the chamber. Analysis methods are provided that can include providing a sample to a chamber and selectively retaining at least a portion of the first analyte of the sample within the chamber without retaining at least a portion of the second analyte within the chamber. Analysis methods can also include providing a sample to a chamber housing an active substrate, contacting at least a portion of the sample with the substrate, and ionizing the portion of the sample.

In one implementation, processes for designing mass separators from a series of mass separator electric field data and processes for designing an ion trap from a range of data pairs and a mass analyzer scale are provided. Methods for producing mass separators including ion traps having Z/rratios from about 0.84 to about 1.2 are also provided. Mass spectrometers are al provided that can include mass separators in tandem with one being an ion trap having a Z/rratio between 0.84 and 1.2. The present invention also provides methods for analyzing samples using mass separators having first and second sets of components defining a volume with a ratio of a distance from the center of the volume to a surface of the first component to a distance from the center of the volume to a surface of the second component being between 0.84 and 1.2.

Mass separators

The present invention relates to a mass spectrometer, and more specifically a portable mass spectrometer. In one implementation, the mass spectrometer includes a toroidal transformer. In another implementation, the mass spectrometer includes feedback circuitry to monitor signals applied in the mass spectrometer.

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Brookston, IN, United States of America

Garth E Patterson