Allegheny-singer Research Institute

University of Michigan

Colorado State University Research Foundation

Other

University of Pittsburgh

Princeton Trade & Technology, Inc.

Garth David Ehrlich

James Christopher Post

Geza Erdos

Fen Z Hu

John William Costerton

Patricia Antalis

John Gladitz

Robert M Williams

David H Sherman

Benjamin Janto

Christopher M Rath

Mohamed Emam Labib

Stanislav S Dukhin

Michael Gorry

David C Whitcomb

Theodore Davidson

Joseph Z Glustein

Yingze Zhang

Paul Stoodley

The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.

Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs

Polymeric articles capable of releasing drugs at therapeutic levels over extended periods of time, and methods for producing the extended release articles.

Medical item for long term drug release

A method of prevention of acid rock drainage excludes oxygen from waste rocks that contain ferrous sulfides by building an oxygen bio-barrier over exposed surfaces of the waste rock. The bio-barrier may be formed by applying a slurry to the rock. The slurry may contain several components such as microbial material, one or more nutrients, water or another fluid, and optionally water-absorbent material. The microbial material may include bacteria, algae, fungi or a combination thereof. Additionally, the slurry may contain one or more acid-neutralizing compounds, one or more cellulose-containing substances, and one or more UV protecting agents.

Biofilm remediation of acid mine drainage

A method of in situ treatment of fracture fluid that is contaminated with a heavy metal may include passing a flow of contaminated fracture fluid through a reactor vessel. The reactor vessel may contain a plurality of biofilm retaining structures. Each of the structures may at least be partially coated with a biofilm. Additionally, the biofilm may include a plurality of bacteria retained in a matrix and the matrix may include DNA, protein and carbohydrates produced by the bacteria.

Biofilm remediation of fracture fluid

A method of in situ treatment of wastewater that is contaminated with a heavy metal may include passing a flow of contaminated wastewater through a reactor vessel. The reactor vessel may contain a plurality of biofilm retaining structures. Each of the structures may at least be partially coated with a biofilm. Additionally, the biofilm may include a plurality of bacteria retained in a matrix and the matrix may include DNA, protein and carbohydrates produced by the bacteria.

Biofilm remediation of metal containing wastewater

A DNA sequence ofclone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence ofclone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence ofclone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence ofclone 167_A16 shown in SEQ. ID. NO. 4.

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Selected nucleotide sequences isolated from pathogenic strains of Haemophilus influenzae

A method for determining whether a human patient is susceptible to hereditary pancreatitis. The method comprises the steps of obtaining nucleic acid from the human patient. Then there is the step of checking the nucleic acid for a mutation that indicates hereditary pancreatitis. A primer which reacts with a human trypsinogen gene to identify hereditary pancreatitis. A method for detecting in a human a mutation in a trypsinogen gene indicative of hereditary pancreatitis. The invention comprises the steps of obtaining a sample having DNA of the patient. Then there is the step of processing the sample so the DNA will be recognized by a desired restriction enzyme. Next there is the step of introducing the desired restriction enzyme to the DNA wherein the recognizing of the desired restriction enzyme to the DNA indicates the presence of the mutation.

Method for determining whether a human patient is susceptible to hereditary pancreatitis, and primers therefore

A multiplex assay is provided for the simultaneous detection and discrimination of pathogens that cause bacterial and viral meningitis.

PCR assay for bacterial and viral meningitis

Growing community of inventors

Pittsburgh, PA, United States of America

Garth David Ehrlich