Becton Dickinson and Company Limited

Garry R Harper

Erwin A Vogler

Jane C Graper

An evacuated blood collection assembly includes a plastic container having a plasma-treated inside wall surface and an open end covered by a puncturable septum. The inside wall surface may also be abraded to increase surface area. The invention included a method to make the assembly.

Vacuum actuated blood collection assembly including tube of

A blood collection container is coated on its inside wall with a unitarily immobilized clotting activator. The activator may be applied to the surface by an adhesive or by rendering the inside wall surface sticky with a solvent and partially absorbing the activator into the sticky surface.

Tube having unitary blood coagulation activator and method for its

An additive for a blood collection container is a polyelectrolyte complex having a surface charge which activates clotting of a blood sample in the container. A preferred additive is a crosslinked carboxylated cellulose having a negative charge. The invention includes a blood collection tube having a puncturable stopper in an open end and the additive of the invention deployed therein.

Clot activating polyelectrolyte complex and blood collection assembly

A glass or plastic article, preferably a blood collection tube, has two or more surface regions of different surface chemistry. One region is substantially glass-like and another region is substantially plastic-like. If the tube is glass, a region of the tube adjacent the tube bottom is plastic-like. If the tube is plastic, a region of the tube adjacent the mouth of the tube is be glass-like.

Surface modified blood collection tubes

An additive for a blood collection tube has a wettable surface region and a nonwettable surface region. When a blood sample comes into contact with the wettable surface region, the clotting cascade is initiated. Clot material adheres to the nonwettable surface region. The additive thereby becomes part of the clot and, on centrifugation, becomes part of the pellet and is removed from the serum layer. The invention includes a blood collection tube having the additive therein. The tube may be evacuated and have an open end covered with a septum.

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Raleigh, NC, United States of America

Garry R Harper