Micromass UK Limited

Garry Michael Scott

Martin Raymond Green

Anthony James Gilbert

Jason Lee Wildgoose

Nicholas Lester St Hill

Steven Derek Pringle

Keith George Richardson

Richard Denny

Peter Gerard Spreadbury

Frank Buckley

David Darrell Williams

Anthony Gilbert

A method of mass spectrometry is disclosed comprising digitising a signal output from a detector to provide a first digitised signal. A finite impulse response ('FIR') filter, a digital filter or an echo cancellation filter is applied to the first digitised signal in order to reduce the effect of baseline perturbations, echoes or ringing effects. Alternatively, an analogue signal output from a detector is passed to one or more first power splitters or dividers, wherein one or more first transmission lines are attached to one or more ports of one more said first power splitters or dividers in order to reduce the effect of baseline perturbations, echoes or ringing effects.

Echo cancellation for time of flight analogue to digital converter

A data acquisition system for a TOF mass spectrometer comprises a processing module and a data collection module. The processing module generates a stream of data comprising, for each respective transient of a first scan, a set of time-intensity related parameter pairs. For each new set of data, the data collection module reads out a previous set of data from a previous memory bank, merges that previous set of data with the new set of data, and writes that latest merged set of data into a memory bank other than the previous memory bank. The data acquisition system provides a convenient way to merge sequential sets of time-intensity related parameter pairs for respective transients as a stream of data for a first scan is generated.

Mass spectrometer data acquisition

A method of mass spectrometry is disclosed comprising digitizing a plurality of individual signals or transients and summing the plurality of digitized signals or transients or data relating to the plurality of digitized signals or transients to generate a composite mass spectral data set. The method further comprises determining in relation to the composite mass spectral data set an indication of the proportion of instances that intensity values relating to the individual digitized signals or transients either: (i) exceeded or approached a threshold value; (ii) suffered from saturation or approached saturation; or (iii) resulted from the dynamic range of an ion detector system being exceeded or approached.

Method of recording ADC saturation

A method of processing mass spectral data is disclosed comprising digitizing a first signal output from an ion detector to produce a first digitized signal. A first set of peaks in the first digitized signal is detected and the arrival time Tand peak area Sof one or more peaks in the first set of peaks are determined thereby forming a first list of data pairs, each data pair comprising an arrival time value and a peak area value. One or more data pairs from the first list are then filtered out thereby forming a second reduced list, wherein a data pair is filtered out, attenuated or otherwise rejected from the first list if the peak area value of a data pair in the first list is determined to be less than a threshold peak area.

Method of processing mass spectral data

A Time of Flight Acquisition system is disclosed wherein a digitiser () is used to digitise an acceleration pulse () which is applied to an acceleration electrode of a Time of Flight mass analyzer. The digitiser () is then switched to digitise an ion arrival signal which is output from an ion detector ().

Time of flight acquisition system

A method of processing mass spectral data is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time Tand peak area Sof one or more peaks in the first set of peaks are determined thereby forming a first list of data pairs, each data pair comprising an arrival time value and a peak area value. One or more data pairs from the first list are then filtered out thereby forming a second reduced list, wherein a data pair is filtered out, attenuated or otherwise rejected from the first list if the peak area value of a data pair in the first list is determined to be less than a threshold peak area.

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Wigan, United Kingdom

Garry Michael Scott