The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Near Dublin

The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin

Garrett Ryan

Conor Harkin

Bruce Murphy

James Redmond

Colm McGarvey

Riona Ni Ghriallais

Michael Burke

An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.

Implantable biocompatible expander suitable for treatment of constrictions of body lumen

A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle () with a tip and a hydrogel outlet (), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G') of at least 600 Pa, and a tan δ (G″/G′) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula () having a lumen configured for receipt of the hydrogel delivery needle (), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism () configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.

System and methods for sealing a channel in tissue

A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle () with a tip and a hydrogel outlet (), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G') of at least 600 Pa, and a tan &#x3b4; (G&#x2033;/G) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25&#xb0; C. The system may also comprise a coaxial cannula () having a lumen configured for receipt of the hydrogel delivery needle (), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism () configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.

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Dublin, Ireland

Garrett Ryan