University of Notre Dame Du Lac

Moraski, Garrett

Miller, Marvin J.

Garrett C Moraski

Marvin J Miller

George E Davis

Lowell D Markley

Jonathan Stefely

Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections.

Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection

Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.

Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same

The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth ofand/or, and methods of treating, preventing, and/or amelioratingand/orinfections in a subject. In various embodiments, the 5,5-heteroaromatic compound is N-(4-(4-chlorophenoxy)benzyl)-2,6-dimethylimidazo[2,1-b]thiazole-5-carboxamide.

5,5-heteroaromatic anti-infective compounds

Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in a subject, such as using the disclosed heterocyclic anti-cancer agents.

Anti-cancer compounds, synthesis thereof, and methods of using same

Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria.

Growing community of inventors

South Bend, IN, United States of America

Garrett C Moraski