Imagination Technologies Limited

Numed, Inc.

Gareth Morgan

Luke Tilman Peterson

Jeffery W Kelly

Nicholas Lok Yan

Hank Michael James Petrassi

An intraluminal stent includes pluralities of first and second wire segments made from a soft malleable alloy formed into a cylindrical structure. Each of the wire segments is defined by a series of sinusoidal bends formed over the length of each segment, with the initial unformed length of each second wire segment being larger than that of each first wire segment. Each of the first and second wire segments include the same number of sinusoidal bends with the amplitude of the of the sinusoidal bends of the second wire segments being larger than that of the sinusoidal bends of the first wire segments. Adjacent wire segments are conjoined by welds at apices of each sinusoidal bend to form the cylindrical or tubular structure. The first wire segments can form a center portion of the stent and the second wire segments can be provided at either or both ends of the stent, enabling minimized axial shrinkage when the stent is radially expanded from an initial to an expanded diameter and in which the second wire segment at the terminal end of the stent is caused to outwardly flare significantly relative to the remainder of a radially expanded stent.

Stent having reduced axial shrinkage upon radial expansion

In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.

Stabilization of amyloidogenic immunoglobulin light chains

Systems can identify visible surfaces for pixels in an image (portion) to be rendered. A sampling pattern of ray directions is applied to the pixels, so that the sampling pattern of ray directions repeats, and with respect to any pixel, the same ray direction can be found in the same relative position, with respect to that pixel, as for other pixels. Rays are emitted from visible surfaces in the respective ray direction supplied from the sampling pattern. Ray intersections can cause shaders to execute and contribute results to a sample buffer. With respect to shading of a given pixel, ray results from a selected subset of the pixels are used; the subset is selected by identifying a set of pixels, collectively from which rays were traced for the ray directions in the pattern, and requiring that surfaces from which rays were traced for those pixels satisfy a similarity criteria.

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San Francisco, CA, United States of America

Gareth Morgan