Lonza Ag

Gareth-John Griffiths

Walter Brieden

Silvia Lange

A method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl) cyclopenlane-1,2-diols of formula (I): (and/or the enantiomer), where Ris H, C-alkyl, C-cycloalkyl or benzyl and (i) Ris methyl and Ris ethyl, (ii) Ris H and Ris C-alkyl or phenyl or (iii) Rand Rtogether form a group of formula &#x2014;(CH)&#x2014; with n=4 to 6, present as free amines or as salts of di- or tri-basic organic acids, starting from 2-acetyl-2-aza-bicyclo[2.2.1]hept-5-en-3-one of formula (II): (and/or the enantiomer). The method is equally useful, depending on the starting material, for the production of enantiomerically-pure compounds, or mixtures with arbitrary enantiomeric content.

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Visp, Switzerland

Gareth-John Griffiths