Illumina Cambridge Limited

Gareth Jenkins

Kevin L Gunderson

Jonathan Mark Boutell

Molly Min He

Niall Anthony Gormley

Frank J Steemers

Amirali Kia

Igor Yu Goryshin

Jason Richard Betley

Rigo Pantoja

Dmitry K Pokholok

Gary Mark Skinner

Natalie Morrell

Fan Zhang

Wouter Meuleman

Rosamond Jackson

Avgousta Ioannou

Jacqueline Weir

Steven J Norberg

Igor Goryshin

Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.

Contiguity preserving transposition

An apparatus and method for applying a chemistry to samples of interest are provided. The apparatus and method include a flexible tape mounted on an arrangement of guide rollers. Samples of interest (e.g., clusters of DNA templates) are bound to at least one surface of the flexible tape. The method and apparatus further comprise one or more read heads in relation to the flexible tape and a plurality of reservoirs along a path of the flexible tape. The reservoirs comprise liquids comprising chemical reagents for performing the chemistry on the samples of interest bound to the at least one surface of the flexible tape. The method and apparatus further comprise a drive system for driving at least one of the guide rollers to advance the flexible tape into and out of the reservoirs.

Flexible tape-based chemistry apparatus

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New Malden, United Kingdom

Gareth Jenkins