Beecham Group Plc

Smithkline Beecham Corporation

Gareth J Sanger

Gordon Wootton

Kay A Wardle

Helen E Marr

Francis D King

Laramie Mary Gaster

Paul Adrian Wyman

Keith Raymond Mulholland

Guy Anthony Kennett

Gordon S Baxter

Christopher Stuart Dott

Wesley D Miner

Rodney C Young

Mythily Vimal

Alberto J Kaumann

Shirley Katherine Rahman

Alastair David Reith

Richard Anthony Newton

Oliver Lars Rausch

Alberto J Kauman

Elaine Alison Irving

Sharon Bingham

Philip Timothy Davey

Sally Neale Lawson

Patrick Case

A compound which acts as an antagonist at 5-HT receptors is of potential use in the treatment of conditions associated with bladder hypersensitivity, such as urinary incontinence, which is often associated with irritable bowel syndrome (IBS) and a compound which acts as an agonist at 5-HT receptors is of potential use in the treatment of conditions associated with a poorly functioning bladder, such as urinary bladder hypoactivity following prostectomy.

Use of 5-HT4 modulators for the manufacture of a medicament for the treatment of the bladder diseases

The use of orexin receptor antagonists as neuroprotectants, and in the treatment of nausea and vomiting, irritable bowel syndrome and other conditions associated with visceral pain.

Use of orexin receptor antagonists

The use of KIAA0551 polypeptides and polynucleotides in the design of protocols for the treatment of neuropathies, neuropathic pain, inflammatory and chronic pain, neurodegenerative conditions such as Motor Neuron Disease, Parkinson's Disease, Alzheimer's Disease and other dementias, as well as ischaemic damage in neuronal and cardiac tissues, through disease or infectious agents, among others, and diagnostic assays for such conditions. Also disclosed are methods for producing such polypeptides by recombinant techniques.

KIAA0551 polynucleotides and polypeptides use

Use of granisetron for the treatment of postoperative nausea and vomiting

A method of treatment of nausea and vomiting is disclosed which comprises administering to a human or animal subject granisetron and an antiemetic corticosteroid.

Pharmaceutical compositions containing granisetron and dexamethasone

5-HT.sub.4 receptor antagonists

A method of treatment of visceral pain in mammals, including humans, which method comprises the administration to the mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:

Method of treatment of visceral pain

Novel treatment

A method of treatment of emesis, anxiety and/or IBS in mammals, including humans, which method comprises administering an effective amount of a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof:

A method of treatment of migraine, cluster headaches and trigeminal neuralgia, radiation or cytotoxic agent induced nausea and vomiting and/or cardiac arrhythmia in mammals, including humans, which method comprises administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is C.sub.1-6 alkyl;

Treatment of migraine, cluster headaches and trigeminal neuralgia

Treatment of emesis, nausea and vomiting

Method of treating emesis, anxiety and/or IBS

Growing community of inventors

Harlow, United Kingdom

Gareth J Sanger